ArticlePloS one2014
Escitalopram or novel herbal mixture treatments during or following exposure to stress reduce anxiety-like behavior through corticosterone and BDNF modifications.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03843463 (Escitalopram and Language Intervention for Subacute Aphasia), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Escitalopram and Language Intervention for Subacute Aphasia (ELISA)
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Antidepressants versus placebo for generalised anxiety disorder (GAD).The Cochrane database of systematic reviews · 2025Pooled it
- The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies.Psychopharmacology · 2024Pooled it
- Article
- Chronic Trazodone and Citalopram Treatments Increase Trophic Factor and Circadian Rhythm Gene Expression in Rat Brain Regions Relevant for Antidepressant Efficacy.International journal of molecular sciences · 2022Article
- Anxiolytic and antidepressants' effect of Crataegus pinnatifida (Shan Zha): biochemical mechanisms.Translational psychiatry · 2022Article
- Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress.International journal of molecular sciences · 2021Article
- Exploratory study on neurochemical effects of low-intensity pulsed ultrasound in brains of mice.Medical & biological engineering & computing · 2021Article
- Behavioral Characterizing of CD24 Knockout Mouse-Cognitive and Emotional Alternations.Journal of personalized medicine · 2021Article
- An Ethanolic Extract ofFrontiers in pharmacology · 2021Article
- The Volatile Oil ofDrug design, development and therapy · 2021Article
- Cerebral MAO Activity Is Not Altered by a Novel Herbal Antidepressant Treatment.Journal of molecular neuroscience : MN · 2019Article
- Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments.Acta neuropathologica communications · 2019Article
- The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice.Journal of visualized experiments : JoVE · 2018Article
- The Role of Musk in Relieving the Neurodegenerative Changes Induced After Exposure to Chronic Stress.American journal of Alzheimer's disease and other dementias · 2018Article
- Anxiety-like behaviour assessments of adolescent rats after repeated maternal separation during early life.Neuroreport · 2018Article
- GABAJournal of molecular neuroscience : MN · 2018Article
- Escitalopram and NHT normalized stress-induced anhedonia and molecular neuroadaptations in a mouse model of depression.PloS one · 2017Article
- Investigating the stress attenuating potential of furosemide in immobilization and electric foot-shock stress models in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- The forced swim test as a model of depressive-like behavior.Journal of visualized experiments : JoVE · 2015Article
- Long-term Effects of Maternal Separation on Anxiety-Like Behavior and Neuroendocrine Parameters in Adult Balb/c Mice.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety disorders are a major public health concern worldwide. Studies indicate that repeated exposure to adverse experiences early in life can lead to anxiety disorders in adulthood. Current treatments for anxiety disorders are characterized by a low success rate and are associated with a wide variety of side effects. The aim of the present study was to evaluate the anxiolytic effects of a novel herbal treatment, in comparison to treatment with the selective serotonin reuptake inhibitor escitalopram. We recently demonstrated the anxiolytic effects of these treatments in BALB mice previously exposed to one week of stress. In the present study, ICR mice were exposed to post natal maternal separation and to 4 weeks of unpredictable chronic mild stress in adolescence, and treated during or following exposure to stress with the novel herbal treatment or with escitalopram. Anxiety-like behavior was evaluated in the elevated plus maze. Blood corticosterone levels were evaluated using radioimmunoassay. Brain derived neurotrophic factor levels in the hippocampus were evaluated using enzyme-linked immunosorbent assay. We found that (1) exposure to stress in childhood and adolescence increased anxiety-like behavior in adulthood; (2) the herbal treatment reduced anxiety-like behavior, both when treated during or following exposure to stress; (3) blood corticosterone levels were reduced following treatment with the herbal treatment or escitalopram, when treated during or following exposure to stress; (4) brain derived neurotrophic factor levels in the hippocampus of mice treated with the herbal treatment or escitalopram were increased, when treated either during or following exposure to stress. This study expands our previous findings and further points to the proposed herbal compound's potential to be highly efficacious in treating anxiety disorders in humans.
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Registered trials
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