ArticleHeredity2014
MHC class II diversity of koala (Phascolarctos cinereus) populations across their range.
Article in Heredity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Development and Validation of a Standardised Genomic Tool for Conservation Management of the Koala (Animals : an open access journal from MDPI · 2025Article
- Koala MHCII association with chlamydia infertility remains equivocal: a need for new research approaches.Scientific reports · 2024Article
- Using bioinformatics to investigate functional diversity: a case study of MHC diversity in koalas.Immunogenetics · 2024Article
- Immunohistochemical characterization of the immune cell response during chlamydial infection in the male and female koala (Veterinary pathology · 2024Article
- Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- High-throughput immunogenetic typing of koalas suggests possible link between MHC alleles and cancers.Immunogenetics · 2020Article
- Article
- Characterisation of MHC class I genes in the koala.Immunogenetics · 2018Article
- Article
- Transcriptome analyses of immune tissues from three Japanese frogs (genus Rana ) reveals their utility in characterizing major histocompatibility complex class II.BMC genomics · 2017Article
- Limited polymorphism of the functional MHC class II B gene in the black-spotted frog (Ecology and evolution · 2017Article
- Genetic wealth, population health: Major histocompatibility complex variation in captive and wild ring-tailed lemurs (Ecology and evolution · 2017Article
- Article
- Immunomics of the koala (Phascolarctos cinereus).Immunogenetics · 2015Article
- A transcriptome resource for the koala (Phascolarctos cinereus): insights into koala retrovirus transcription and sequence diversity.BMC genomics · 2014Article
- Identification of MHCII variants associated with chlamydial disease in the koala (Phascolarctos cinereus).PeerJ · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major histocompatibility complex class II (MHCII) genes code for proteins that bind and present antigenic peptides and trigger the adaptive immune response. We present a broad geographical study of MHCII DA β1 (DAB) and DB β1 (DBB) variants of the koala (Phascolarctos cinereus; n=191) from 12 populations across eastern Australia, with a total of 13 DAB and 7 DBB variants found. We identified greater MHCII variation and, possibly, additional gene copies in koala populations in the north (Queensland and New South Wales) relative to the south (Victoria), confirmed by STRUCTURE analyses and genetic differentiation using analysis of molecular variance. The higher MHCII diversity in the north relative to south could potentially be attributed to (i) significant founder effect in Victorian populations linked to historical translocation of bottlenecked koala populations and (ii) increased pathogen-driven balancing selection and/or local genetic drift in the north. Low MHCII genetic diversity in koalas from the south could reduce their potential response to disease, although the three DAB variants found in the south had substantial sequence divergence between variants. This study assessing MHCII diversity in the koala with historical translocations in some populations contributes to understanding the effects of population translocations on functional genetic diversity.
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