ArticleToxicological sciences : an official journal of the Society of Toxicology2014
Developmental exposure to concentrated ambient ultrafine particulate matter air pollution in mice results in persistent and sex-dependent behavioral neurotoxicity and glial activation.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 2 of them syntheses that pooled it.
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Who cites it
97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Effects of prenatal exposure to NOEnvironmental science and pollution research international · 2020Pooled it
- Outdoor Air Pollution and Brain Structure and Function From Across Childhood to Young Adulthood: A Methodological Review of Brain MRI Studies.Frontiers in public health · 2019Pooled it
- Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study.Annals of neurology · 2015Trial
- A review of indoor air quality interventions and child neurobehavioral outcomes.Pediatric research · 2026Review
- Long-Term Exposure to Air Pollution and Risk and Prognosis of Motor Neuron Disease.JAMA neurology · 2026Article
- Alterations in neuroinflammatory and neurodegenerative biomarkers among long-term residents of a critically polluted area: a cross-sectional comparative study.Scientific reports · 2025Article
- Effects of air and light pollution on brain and behavioral function: Potential synergy.Neuroscience and biobehavioral reviews · 2025Review
- The role of air pollution in epilepsy: a better understanding is needed.Arquivos de neuro-psiquiatria · 2025Review
- Fine particulate matter, suicide, and urbanicity in South Korea: A nationwide time-stratified cases-crossover study.iScience · 2025Article
- Association between chronic PMBMC public health · 2025Article
- Air Pollution Exposure, Prefrontal Connectivity, and Emotional Behavior in Early Adolescence.Research report (Health Effects Institute) · 2025Article
- Association between Ambient Ultrafine Particles and Neurodevelopmental Delay in Preschoolers in Shanghai, China.Environment & health (Washington, D.C.) · 2025Article
- The protracted neurotoxic consequences in mice of developmental exposures to inhaled iron nanoparticles alone or in combination with SOFrontiers in behavioral neuroscience · 2025Article
- Aerosol size determination via light scattering of viruses and protein complexes.Communications physics · 2025Article
- Therapeutic potential of transient receptor potential (TRP) channels in psychiatric disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Male-biased vulnerability of mouse brain tryptophan/kynurenine and glutamate systems to adolescent exposures to concentrated ambient ultrafine particle air pollution.Neurotoxicology · 2024Article
- Outdoor air pollution and brain development in childhood and adolescence.Trends in neurosciences · 2024Review
- Causal relationship and shared genes between air pollutants and amyotrophic lateral sclerosis: A large-scale genetic analysis.CNS neuroscience & therapeutics · 2024Article
- Review
- Nitrooxidative Stress and Neuroinflammation Caused by Air Pollutants Are Associated with the Biological Markers of Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2024Review
37 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The brain appears to be a target of air pollution. This study aimed to further ascertain behavioral and neurobiological mechanisms of our previously observed preference for immediate reward (Allen, J. L., Conrad, K., Oberdorster, G., Johnston, C. J., Sleezer, B., and Cory-Slechta, D. A. (2013). Developmental exposure to concentrated ambient particles and preference for immediate reward in mice. Environ. Health Perspect. 121, 32-38), a phenotype consistent with impulsivity, in mice developmentally exposed to inhaled ultrafine particles. It examined the impact of postnatal and/or adult concentrated ambient ultrafine particles (CAPS) or filtered air on another behavior thought to reflect impulsivity, Fixed interval (FI) schedule-controlled performance, and extended the assessment to learning/memory (novel object recognition (NOR)), and locomotor activity to assist in understanding behavioral mechanisms of action. In addition, levels of brain monoamines and amino acids, and markers of glial presence and activation (GFAP, IBA-1) were assessed in mesocorticolimbic brain regions mediating these cognitive functions. This design produced four treatment groups/sex of postnatal/adult exposure: Air/Air, Air/CAPS, CAPS/Air, and CAPS/CAPS. FI performance was adversely influenced by CAPS/Air in males, but by Air/CAPS in females, effects that appeared to reflect corresponding changes in brain mesocorticolimbic dopamine/glutamate systems that mediate FI performance. Both sexes showed impaired short-term memory on the NOR. Mechanistically, cortical and hippocampal changes in amino acids raised the potential for excitotoxicity, and persistent glial activation was seen in frontal cortex and corpus callosum of both sexes. Collectively, neurodevelopment and/or adulthood CAPS can produce enduring and sex-dependent neurotoxicity. Although mechanisms of these effects remain to be fully elucidated, findings suggest that neurodevelopment and/or adulthood air pollution exposure may represent a significant underexplored risk factor for central nervous system diseases/disorders and thus a significant public health threat even beyond current appreciation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.