ArticleEuropean journal of clinical nutrition2014
Revised D-A-CH intake recommendations for folate: how much is needed?
Article in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet-A Randomized Controlled Trial in Healthy Participants.Nutrients · 2019Trial
- The effectiveness of daily supplementation with 400 or 800 µg/day folate in reaching protective red blood folate concentrations in non-pregnant women: a randomized trial.European journal of nutrition · 2018Trial
- Response of Red Blood Cell Folate to Supplementation in Nonpregnant Women is Predictable: A Proposal for Personalized Supplementation.Molecular nutrition & food research · 2018Trial
- Folic acid causes higher prevalence of detectable unmetabolized folic acid in serum than B-complex: a randomized trial.European journal of nutrition · 2016Trial
- Wheatgrass (Triticum aestivum) growth and nutrient composition in Aquaponics with African catfish (Clarias gariepinus) using Einheitserde and coconut: vermiculite substrates.Environmental science and pollution research international · 2025Article
- Biological, dietetic and pharmacological properties of vitamin BNPJ science of food · 2025Review
- Nutritional Strategies for Chronic Craniofacial Pain and Temporomandibular Disorders: Current Clinical and Preclinical Insights.Nutrients · 2024Review
- Review
- Dietary Intake of Folate and Assessment of the Folate Deficiency Prevalence in Slovenia Using Serum Biomarkers.Nutrients · 2021Article
- Nutritional Supplements for the Treatment of Neuropathic Pain.Biomedicines · 2021Review
- Dynamics and interactions of cobalamin and folate status during advanced aging - a longitudinal study in a community-dwelling cohort with multiple follow-ups.Nutrition journal · 2020Article
- Promising Tropical Fruits High in Folates.Foods (Basel, Switzerland) · 2019Article
- The Revised D-A-CH-Reference Values for the Intake of Vitamin BMolecular nutrition & food research · 2019Article
- Microalgae a Superior Source of Folates: Quantification of Folates in Halophile Microalgae by Stable Isotope Dilution Assay.Frontiers in bioengineering and biotechnology · 2019Article
- Diet and Lifestyle Before and During Pregnancy - Practical Recommendations of the Germany-wide Healthy Start - Young Family Network.Geburtshilfe und Frauenheilkunde · 2018Article
- Assessment of Dietary Intake of Long-Distance Race Car Drivers-A Pilot Study.Sports (Basel, Switzerland) · 2018Article
- Durian Fruits Discovered as Superior Folate Sources.Frontiers in nutrition · 2018Article
- Simulation of Food Folate Digestion and Bioavailability of an Oxidation Product of 5-Methyltetrahydrofolate.Nutrients · 2017Article
- Assessing Volumetric Absorptive Microsampling Coupled with Stable Isotope Dilution Assay and Liquid Chromatography-Tandem Mass Spectrometry as Potential Diagnostic Tool for Whole Blood 5-Methyltetrahydrofolic Acid.Frontiers in nutrition · 2017Article
- Revised Reference Values for Potassium Intake.Annals of nutrition & metabolism · 2017Article
Corrections and comments
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Authors and funding
9 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The D-A-CH reference value (D-A-CH arises from the initial letters of the common country identification for the countries Germany (D), Austria (A) and Switzerland (CH)) for folate equivalents had been set at 400 μg/d for adults in the year 2000. By that time, the prevention of cardiovascular diseases through reduction of homocysteine was considered an important target of the reference value. Since that time a number of research papers revealed that in spite of an inverse association between folate-rich diet and chronic diseases, a preventive effect of folic acid intake on cardiovascular events was not supported by randomized controlled trials, and the reduction of plasma homocysteine levels to around 10-12 μmol/l did not reduce the risk for thromboembolic and cardiovascular diseases in persons already affected by these diseases. These results together with the observation that folate intakes below 400 μg/d result in a sufficient folate status justified a review of the current literature and-consequently-a reduction of the reference value to 300 μg/d for adults. This reference value is expressed as dietary folate equivalents that take into account the difference in bioavailability between folic acid and all types of folates in food. The recommendation to take a daily supplement of 400 μg of synthetic folic acid for women who intend to get pregnant and until the end of the first trimester of pregnancy is maintained.
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