ArticleHereditary cancer in clinical practice2014
Long-term satisfaction and quality of life following risk reducing surgery in BRCA1/2 mutation carriers.
Article in Hereditary cancer in clinical practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Beyond BRCA: A scoping review of person-centred care for women diagnosed with a BRCA gene mutation.BMJ open · 2025Article
- Psychosocial outcomes after varying risk management strategies in women at increased familial breast cancer risk: a mixed methods study of patient and partner outcomes.Annals of the Royal College of Surgeons of England · 2024Article
- Interventions to improve psychosocial well-being in female BRCA-mutation carriers following risk-reducing surgery.The Cochrane database of systematic reviews · 2019Review
- Economic modeling of risk-adapted screen-and-treat strategies in women at high risk for breast or ovarian cancer.The European journal of health economics : HEPAC : health economics in prevention and care · 2019Article
- Concerns and Expectations of Risk-Reducing Surgery in Women with Hereditary Breast and Ovarian Cancer Syndrome.Journal of clinical medicine · 2019Article
- Reproductive health care across the lifecourse of the female cancer patient.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Review
- Different Patterns of Risk Reducing Decisions in Affected or Unaffected BRCA Pathogenic Variant Carriers.Cancer research and treatment · 2019Article
- Adaptation of couples living with a high risk of breast/ovarian cancer and the association with risk-reducing surgery.Familial cancer · 2018Article
- Risk-reducing mastectomy rates in the US: a closer examination of the Angelina Jolie effect.Breast cancer research and treatment · 2018Article
- Cost-effectiveness of different strategies to prevent breast and ovarian cancer in German women with a BRCA 1 or 2 mutation.The European journal of health economics : HEPAC : health economics in prevention and care · 2018Article
- Experience and Expectations of Ovarian Cancer Patients in Australia.Journal of oncology · 2018Article
- Ovarian Cancer Prevention in High-risk Women.Clinical obstetrics and gynecology · 2017Review
- Quality of Life and Psychological State in Chinese Breast Cancer Patients Who Received BRCA1/2 Genetic Testing.PloS one · 2016Article
- The evolution of cancer surgery and future perspectives.Nature reviews. Clinical oncology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAs BRCA1/2 testing becomes more routine, questions remain about long-term satisfaction and quality of life following testing. Previously, we described long term distress and risk management outcomes among women with BRCA1/2 mutations. This study addresses positive psychological outcomes in BRCA1/2 carriers, describing decision satisfaction and quality of life in the years following testing.
methodsWe evaluated satisfaction with testing and management decisions among 144 BRCA1/2 carriers. Prior to genetic testing, we assessed family history, sociodemographics and distress. At a mean of 5.3 years post-testing, we assessed management decisions, satisfaction with decisions and, among women with cancer, quality of life.
resultsOverall, satisfaction with decision making was high. Women who had risk reducing mastectomy or oophorectomy were more satisfied with management decisions. Participants who obtained a risk reducing oophorectomy were more satisfied with their genetic testing decision. Among affected carriers, high pretest anxiety was associated with poorer quality of life and having had risk reducing mastectomy prior to testing was associated with better quality of life. The negative impact of pre-test anxiety was diminished among women who had mastectomies before testing.
conclusionsBRCA1/2 carriers are satisfied with their testing and risk management decisions and report good quality of life years after testing. Having risk reducing surgery predicts increased satisfaction and improved quality of life.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.