ArticleCritical care (London, England)2014
Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort.
Article in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Global Perspective ofInternational journal of environmental research and public health · 2022Pooled it
- Pooled it
- Chlamydia psittaci (psittacosis) as a cause of community-acquired pneumonia: a systematic review and meta-analysis.Epidemiology and infection · 2017Pooled it
- Adjunctive Corticotherapy for Community Acquired Pneumonia: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Traditional Chinese Medicine treatment with syndrome differentiation for patients with severe community-acquired pneumonia: a multicenter, randomized, placebo-controlled trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Trial
- Risk factors for mortality in patients admitted to intensive care units with pneumonia.Respiratory research · 2016Trial
- AKI in Severe Legionnaires' Disease in Intensive Care Unit.Kidney international reports · 2026Article
- Non-directed bronchoalveolar lavage: improving the quality and timing of pneumonia diagnosis in mechanically ventilated patients in the intensive care unit.BMJ open quality · 2026Article
- Application Value of Metagenomic Next-Generation Sequencing Using Bronchoalveolar Lavage Fluid and Blood Samples in Patients with Severe Pneumonia Complicated with Bloodstream Infection.Polish journal of microbiology · 2026Article
- Final diagnoses and mortality rates in ambulance patients administered nebulized β2-agonists bronchodilators.Internal and emergency medicine · 2025Observational
- Incidence and risk factor of sepsis in patients with severe community-acquired pneumonia: a Chinese, single-center, retrospective study.BMC infectious diseases · 2025Observational
- Development and validation of a predictive model for hospital mortality in patients with community-acquired pneumonia admitted to the intensive care unit.The Journal of international medical research · 2025Article
- Corticosteroid and antimicrobial therapy in macrolide-resistant pneumococcal pneumonia porcine model.Intensive care medicine experimental · 2025Article
- Efficacy of Lefamulin for Community-Acquired Bacterial Pneumonia (CABP) Patients: Pooled Analysis of the Lefamulin Evaluation Against Pneumonia (LEAP) 1, LEAP 2 and LEAP China Trials.Infection and drug resistance · 2025Review
- Severe community-acquired pneumonia compared to severe community-acquired Acinetobacter baumannii pneumonia in Reunion Island: A retrospective study.Tropical medicine & international health : TM & IH · 2025Article
- MALAT1 predicts the prognosis of severe community-acquired pneumonia in pediatric patients.BMC pulmonary medicine · 2024Article
- Case Report: Severe Community-Acquired Pneumonia in Réunion Island due to Acinetobacter baumannii.The American journal of tropical medicine and hygiene · 2024Article
- Candent issues in pneumonia. Reflections from the Fifth Annual Meeting of Spanish Experts 2023.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024Review
- Critical care outcomes in decompensated cirrhosis: a United States national inpatient sample cross-sectional study.Critical care (London, England) · 2024Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 4 countries.
Funding
Abstract
introductionCommunity acquired pneumonia (CAP) is the most common infectious reason for admission to the Intensive Care Unit (ICU). The GenOSept study was designed to determine genetic influences on sepsis outcome. Phenotypic data was recorded using a robust clinical database allowing a contemporary analysis of the clinical characteristics, microbiology, outcomes and independent risk factors in patients with severe CAP admitted to ICUs across Europe.
methodsKaplan-Meier analysis was used to determine mortality rates. A Cox Proportional Hazards (PH) model was used to identify variables independently associated with 28-day and six-month mortality.
resultsData from 1166 patients admitted to 102 centres across 17 countries was extracted. Median age was 64 years, 62% were male. Mortality rate at 28 days was 17%, rising to 27% at six months. Streptococcus pneumoniae was the commonest organism isolated (28% of cases) with no organism identified in 36%. Independent risk factors associated with an increased risk of death at six months included APACHE II score (hazard ratio, HR, 1.03; confidence interval, CI, 1.01-1.05), bilateral pulmonary infiltrates (HR1.44; CI 1.11-1.87) and ventilator support (HR 3.04; CI 1.64-5.62). Haematocrit, pH and urine volume on day one were all associated with a worse outcome.
conclusionsThe mortality rate in patients with severe CAP admitted to European ICUs was 27% at six months. Streptococcus pneumoniae was the commonest organism isolated. In many cases the infecting organism was not identified. Ventilator support, the presence of diffuse pulmonary infiltrates, lower haematocrit, urine volume and pH on admission were independent predictors of a worse outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.