Evidence map›Paper›PMID 24690370›Full record

Trial reportJournal of psychiatry & neuroscience : JPN2014

Impact of acute administration of escitalopram on the processing of emotional and neutral images: a randomized crossover fMRI study of healthy women.

Tim Outhred, Pritha Das, Kim L Felmingham, Richard A Bryant, Pradeep J Nathan, Gin S Malhi, Andrew H Kemp

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychiatry & neuroscience : JPN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  3. Effects of Anodal Transcranial Direct Current Stimulation and Serotonergic Enhancement on Memory Performance in Young and Older Adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
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  11. Selective serotonin reuptake inhibitor treatment retunes emotional valence in primate ventral striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  12. Article
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  14. Increased recruitment of cognitive control in the presence of traumatic stimuli in complex PTSD.European archives of psychiatry and clinical neuroscience · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Tim OuthredDiscipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, Australia SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia.
Pritha DasDiscipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, Australia CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Australia Advanced Research and Clinical Highfield Imaging (ARCHI), University of Sydney, Royal North Shore Hospital, Australia.
Kim L FelminghamSchool of Psychology, University of Tasmania, Hobart, Australia.
Richard A BryantSchool of Psychology, University of New South Wales, Kensington, Australia.
Pradeep J NathanDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom School of Psychology and Psychiatry, Monash University, Australia.
Gin S MalhiDiscipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, Australia CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Australia Advanced Research and Clinical Highfield Imaging (ARCHI), University of Sydney, Royal North Shore Hospital, Australia.
Andrew H KempDiscipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, Australia SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Australia Advanced Research and Clinical Highfield Imaging (ARCHI), University of Sydney, Royal North Shore Hospital, Australia University Hospital, University of São Paulo, São Paulo SP, Brazil.
Hospital Universitário da Universidade de São Paulo · BRRoyal North Shore Hospital · AUMonash University · AUUniversity of Tasmania · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute neural effects of antidepressant medication on emotion processing biases may provide the foundation on which clinical outcomes are based. Along with effects on positive and negative stimuli, acute effects on neutral stimuli may also relate to antidepressant efficacy, yet these effects are still to be investigated. The present study therefore examined the impact of a single dose of the selective serotonin reuptake inhibitor escitalopram (20 mg) on positive, negative and neutral stimuli using pharmaco-fMRI.

methodsWithin a double-blind, randomized, placebo-controlled crossover design, healthy women completed 2 sessions of treatment administration and fMRI scanning separated by a 1-week washout period.

resultsWe enrolled 36 women in our study. When participants were administered escitalopram relative to placebo, left amygdala activity was increased and right inferior frontal gyrus (IFG) activity was decreased during presentation of positive pictures (potentiation of positive emotion processing). In contrast, escitalopram was associated with decreased left amygdala and increased right IFG activity during presentation of negative pictures (attenuation of negative emotion processing). In addition, escitalopram decreased right IFG activity during the processing of neutral stimuli, akin to the effects on positive stimuli (decrease in negative appraisal). LIMITATIONS: Although we used a women-only sample to reduce heterogeneity, our results may not generalize to men. Potential unblinding, which was related to the subjective occurrence of side effects, occurred in the study; however, manipulation check analyses demonstrated that results were not impacted.

conclusionThese novel findings demonstrate that a single dose of the commonly prescribed escitalopram facilitates a positive information processing bias. These findings provide an important lead for better understanding effects of antidepressant medication.

Indexed as

AdultBrainBrain MappingCitalopramCross-Over StudiesDouble-Blind MethodEmotionsFemaleHumansMagnetic Resonance ImagingPhotic StimulationSelective Serotonin Reuptake InhibitorsVisual PerceptionCitalopramSelective Serotonin Reuptake Inhibitors

Identifiers

PMID24690370
PMCPMC4074238
OpenAlexW2001094695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.