ArticleBiological psychiatry2014
Abnormal cortical growth in schizophrenia targets normative modules of synchronized development.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Implicit Mentalizing in Patients With Schizophrenia: A Systematic Review and Meta-Analysis.Frontiers in psychology · 2022Pooled it
- Thalamic Subregion Alterations and Short-Chain Fatty Acids in Schizophrenia and Ultra-High-Risk Individuals: A Cross-Sectional Study.Alpha psychiatry · 2026Article
- Normative modeling reveals functional connectivity heterogeneity in internet gaming disorder.Annals of general psychiatry · 2026Article
- MRI signatures of cortical microstructure in human development align with oligodendrocyte cell-type expression.Nature communications · 2025Article
- Structure-function coupling changes in first-episode, treatment-naïve schizophrenia correlate with cell type-specific transcriptional signature.BMC medicine · 2024Article
- Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns.BMC medicine · 2023Article
- Analysis of Connectome Graphs Based on Boundary Scale.Sensors (Basel, Switzerland) · 2023Article
- The Interplay of Oxytocin and Attachment in Schizophrenic Patients: An fMRI Study.Brain sciences · 2023Article
- Gene transcriptional expression of cortical thinning during childhood and adolescence.Human brain mapping · 2023Article
- Heterogeneous brain dynamic functional connectivity patterns in first-episode drug-naive patients with major depressive disorder.Human brain mapping · 2023Article
- Functional neurodevelopment of working memory in early-onset schizophrenia: A longitudinal FMRI study.Schizophrenia research. Cognition · 2022Article
- Higher-order brain regions show shifts in structural covariance in adolescent marmosets.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Grey and white matter microstructure is associated with polygenic risk for schizophrenia.Molecular psychiatry · 2021Article
- Identifying super-feminine, super-masculine and sex-defining connections in the human braingraph.Cognitive neurodynamics · 2021Article
- Charting the human amygdala development across childhood and adolescence: Manual and automatic segmentation.Developmental cognitive neuroscience · 2021Article
- Improving the predictive potential of diffusion MRI in schizophrenia using normative models-Towards subject-level classification.Human brain mapping · 2021Article
- Article
- Strategies to solve the reverse inference fallacy in future MRI studies of schizophrenia: a review.Brain imaging and behavior · 2021Review
- The Graph of Our Mind.Brain sciences · 2021Article
- Investigating aberrantly expressed microRNAs in peripheral blood mononuclear cells from patients with treatment‑resistant schizophrenia using miRNA sequencing and integrated bioinformatics.Molecular medicine reports · 2020Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSchizophrenia is a disorder of brain connectivity and altered neurodevelopmental processes. Cross-sectional case-control studies in different age groups have suggested that deficits in cortical thickness in childhood-onset schizophrenia may normalize over time, suggesting a disorder-related difference in cortical growth trajectories.
methodsWe acquired magnetic resonance imaging scans repeated over several years for each subject, in a sample of 106 patients with childhood-onset schizophrenia and 102 age-matched healthy volunteers. Using semiparametric regression, we modeled the effect of schizophrenia on the growth curve of cortical thickness in ~80,000 locations across the cortex, in the age range 8 to 30 years. In addition, we derived normative developmental modules composed of cortical regions with similar maturational trajectories for cortical thickness in typical brain development.
resultsWe found abnormal nonlinear growth processes in prefrontal and temporal areas that have previously been implicated in schizophrenia, distinguishing for the first time between cortical areas with age-constant deficits in cortical thickness and areas whose maturational trajectories are altered in schizophrenia. In addition, we showed that when the brain is divided into five normative developmental modules, the areas with abnormal cortical growth overlap significantly only with the cingulo-fronto-temporal module.
conclusionsThese findings suggest that abnormal cortical development in schizophrenia may be modularized or constrained by the normal community structure of developmental modules of the human brain connectome.
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