ArticleBiomedical optics express2014
Detection of swelling of single isolated mitochondrion with optical microscopy.
Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Antioxidant Effects of Exogenous Mitochondria: The Role of Outer Membrane Integrity.Antioxidants (Basel, Switzerland) · 2025Article
- Direct Analysis of Mitochondrial Damage Caused by Misfolded/Destabilized Proteins.International journal of molecular sciences · 2022Article
- Analysis of Mitochondrial Calcium Retention Capacity in Cultured Cells: Permeabilized Cells Versus Isolated Mitochondria.Frontiers in physiology · 2021Article
- The very low number of calcium-induced permeability transition pores in the single mitochondrion.The Journal of general physiology · 2020Article
- PCSK9 inhibitor and atorvastatin reduce cardiac impairment in ovariectomized prediabetic rats via improved mitochondrial function and CaJournal of cellular and molecular medicine · 2020Article
- Significant correlation between refractive index and activity of mitochondria: single mitochondrion study.Biomedical optics express · 2015Article
- Biochemical and biophysical characterization of an unexpected bacteriolytic activity of VanX, a member of the vancomycin-resistance vanA gene cluster.The Journal of biological chemistry · 2014Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Volume regulation under osmotic loading is one of the most fundamental functions in cells and organelles. However, the effective method to detect volume changes of a single organelle has not been developed. Here, we present a novel technique for detecting volume changes of a single isolated mitochondrion in aqueous solution based on the transmittance of the light through the mitochondrion. We found that 70% and 21% of mitochondria swelled upon addition of a hypotonic solution and Ca(2+), respectively. These results show the potential of the present technique to detect the physiological volume changes of individual small organelles such as mitochondria.
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