ArticleEuropean journal of microbiology & immunology2012
Campylobacter jejuni induces extra-intestinal immune responses via Toll-like-receptor-4 signaling in conventional IL-10 deficient mice with chronic colitis.
Article in European journal of microbiology & immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Campylobacter in Africa - A specific viewpoint.European journal of microbiology & immunology · 2023Review
- Protective Application of Chinese Herbal Compounds and Formulae in Intestinal Inflammation in Humans and Animals.Molecules (Basel, Switzerland) · 2023Review
- Resveratrol PreventsFrontiers in pharmacology · 2021Article
- Novel ClinicalMicroorganisms · 2020Review
- Immunopathological properties of theGut pathogens · 2019Article
- Protease Activity ofFrontiers in cellular and infection microbiology · 2019Article
- Multidrug-resistant Pseudomonas aeruginosa aggravates inflammatory responses in murine chronic colitis.Scientific reports · 2018Article
- Small Intestinal Pro-Inflammatory Immune Responses FollowingEuropean journal of microbiology & immunology · 2017Article
- Microbiota Composition and Immune Responses DuringEuropean journal of microbiology & immunology · 2017Article
- Intestinal and Systemic Immune Responses upon Multi-drug ResistantFrontiers in microbiology · 2017Article
- Article
- Toll-like receptor-4 differentially mediates intestinal and extra-intestinal immune responses upon multi-drug resistantGut pathogens · 2017Article
- The Role of IL-23, IL-22, and IL-18 in Campylobacter Jejuni Infection of Conventional Infant Mice.European journal of microbiology & immunology · 2016Article
- Colonic Expression of Genes Encoding Inflammatory Mediators and Gelatinases During Campylobacter Jejuni Infection of Conventional Infant Mice.European journal of microbiology & immunology · 2016Article
- Toll-Like Receptor-4 Dependent Intestinal Gene Expression During Arcobacter Butzleri Infection of Gnotobiotic Il-10 Deficient Mice.European journal of microbiology & immunology · 2016Article
- Intestinal Expression of Genes Encoding Inflammatory Mediators and Gelatinases During Arcobacter Butzleri Infection of Gnotobiotic Il-10 Deficient Mice.European journal of microbiology & immunology · 2016Article
- Toll-Like Receptor-4 Dependent Small Intestinal Immune Responses Following Murine Arcobacter Butzleri Infection.European journal of microbiology & immunology · 2015Article
- Article
- Survey of extra-intestinal immune responses in asymptomatic long-term Campylobacter jejuni-infected mice.European journal of microbiology & immunology · 2013Article
- Can microbiota transplantation abrogate murine colonization resistance against Campylobacter jejuni?European journal of microbiology & immunology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter jejuni is one of the predominant causes for foodborne bacterial infections worldwide. We investigated whether signaling of C. jejuni-lipoproteins and -lipooligosaccharide via Toll-like-receptor (TLR) -2 and -4, respectively, is inducing intestinal and extra-intestinal immune responses following infection of conventional IL-10(-/-) mice with chronic colitis. At day 3 following oral infection, IL-10(-/-) mice lacking TLR-2 or TLR-4 harbored comparable C. jejuni strain ATCC 43431 loads in their colon. Interestingly, infected TLR-4(-/-) IL-10(-/-) mice displayed less compromized epithelial barrier function as indicated by lower translocation rates of live gut commensals into mesenteric lymphnodes (MLNs), and exhibited less distinct B lymphocyte responses in their colonic mucosa as compared to naїve IL-10(-/-) controls. Furthermore, in extra-intestinal compartments such as MLNs and spleens, abundance of myeloid cells was less distinct whereas relative percentages of activated T helper cells and cytotoxic T cells were higher in spleens and dendritic cells more abundant in MLNs of infected IL-10(-/-) animals lacking TLR-4 as compared to IL-10(-/-) controls. Taken together, in conventionally colonized IL-10(-/-) mice, TLR-4, but not TLR-2, is involved in mediating extra-intestinal pro-inflammatory immune responses following C. jejuni infection. Thus, conventional IL-10(-/-) mice are well suited to further dissect mechanisms underlying Campylobacter infections in vivo.
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