ReviewComputational and structural biotechnology journal2012
Engineering microbes for plant polyketide biosynthesis.
Review in Computational and structural biotechnology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Hydrogen Peroxide and Vitexin in the Signaling and Defense Responses ofPlants (Basel, Switzerland) · 2025Article
- Integrated physiological and transcriptomic analysis reveals the key pathways ofFrontiers in plant science · 2025Article
- Stable Platform for Mevalonate Bioproduction from COACS sustainable chemistry & engineering · 2024Article
- Design and Assembly of a Biofactory for (2Biomolecules · 2023Article
- Chemoenzymatic approaches to plant natural product inspired compounds.Natural product reports · 2022Review
- Biotransformation of Benzoate to 2,4,6-Trihydroxybenzophenone by EngineeredMolecules (Basel, Switzerland) · 2021Article
- Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production.Metabolic engineering · 2020Article
- Enhancing glutaric acid production in Escherichia coli by uptake of malonic acid.Journal of industrial microbiology & biotechnology · 2020Article
- Engineering Plant Secondary Metabolism in Microbial Systems.Plant physiology · 2019Article
- A cell-free platform for the prenylation of natural products and application to cannabinoid production.Nature communications · 2019Article
- Engineering microbial hosts for production of bacterial natural products.Natural product reports · 2016Review
- Metabolic engineering of a tyrosine-overproducing yeast platform using targeted metabolomics.Microbial cell factories · 2015Article
- Heterologous production of curcuminoids.Microbiology and molecular biology reviews : MMBR · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyketides are an important group of secondary metabolites, many of which have important industrial applications in the food and pharmaceutical industries. Polyketides are synthesized from one of three classes of enzymes differentiated by their biochemical features and product structure: type I, type II or type III polyketide synthases (PKSs). Plant type III PKS enzymes, which will be the main focus of this review, are relatively small homodimeric proteins that catalyze iterative decarboxylative condensations of malonyl units with a CoA-linked starter molecule. This review will describe the plant type III polyketide synthetic pathway, including the synthesis of chalcones, stilbenes and curcuminoids, as well as recent work on the synthesis of these polyketides in heterologous organisms. The limitations and bottlenecks of heterologous expression as well as attempts at creating diversity through the synthesis of novel "unnatural" polyketides using type III PKSs will also be discussed. Although synthetic production of plant polyketides is still in its infancy, their potential as useful bioactive compounds makes them an extremely interesting area of study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.