ReviewComputational and structural biotechnology journal2012
Metabolic modelling in the development of cell factories by synthetic biology.
Review in Computational and structural biotechnology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Applications of the Whole-Cell System in the Efficient Biosynthesis of Heme.International journal of molecular sciences · 2023Review
- Machine learning-assisted medium optimization revealed the discriminated strategies for improved production of the foreign and native metabolites.Computational and structural biotechnology journal · 2023Article
- Article
- Error propagation in constraint-based modeling of Chinese hamster ovary cells.Biotechnology journal · 2021Article
- Metabolic modeling and response surface analysis of an Escherichia coli strain engineered for shikimic acid production.BMC systems biology · 2018Article
- Designing overall stoichiometric conversions and intervening metabolic reactions.Scientific reports · 2015Article
- Shikimic Acid Production in Escherichia coli: From Classical Metabolic Engineering Strategies to Omics Applied to Improve Its Production.Frontiers in bioengineering and biotechnology · 2015Review
- Succinate Overproduction: A Case Study of Computational Strain Design Using a Comprehensive Escherichia coli Kinetic Model.Frontiers in bioengineering and biotechnology · 2014Article
- Escherichia coli redox mutants as microbial cell factories for the synthesis of reduced biochemicals.Computational and structural biotechnology journal · 2012Review
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Cell factories are commonly microbial organisms utilized for bioconversion of renewable resources to bulk or high value chemicals. Introduction of novel production pathways in chassis strains is the core of the development of cell factories by synthetic biology. Synthetic biology aims to create novel biological functions and systems not found in nature by combining biology with engineering. The workflow of the development of novel cell factories with synthetic biology is ideally linear which will be attainable with the quantitative engineering approach, high-quality predictive models, and libraries of well-characterized parts. Different types of metabolic models, mathematical representations of metabolism and its components, enzymes and metabolites, are useful in particular phases of the synthetic biology workflow. In this minireview, the role of metabolic modelling in synthetic biology will be discussed with a review of current status of compatible methods and models for the in silico design and quantitative evaluation of a cell factory.
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Registered trials
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