Evidence map›Paper›PMID 24688664›Full record

ReviewComputational and structural biotechnology journal2012

Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products.

Ahmed Zahoor, Steffen N Lindner, Volker F Wendisch

Abstract readReview
In one paragraph

Review in Computational and structural biotechnology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Response surface-based media optimization for astaxanthin production inFrontiers in bioengineering and biotechnology · 2025
    Article
  4. Review
  5. Article
  6. Glucosylation of Isoeugenol and Monoterpenes inMolecules (Basel, Switzerland) · 2023
    Article
  7. Article
  8. C-di-AMP Is a Second Messenger inMicroorganisms · 2023
    Article
  9. Metabolic Engineering ofMicroorganisms · 2022
    Article
  10. Article
  11. Shikimate Metabolic Pathway Engineering inJournal of microbiology and biotechnology · 2021
    Article
  12. Review
  13. Engineering in life sciences · 2020
    Article
  14. Article
  15. Whole Cell Actinobacteria as Biocatalysts.Frontiers in microbiology · 2019
    Review
  16. Recent Advances of L-ornithine Biosynthesis in Metabolically EngineeredFrontiers in bioengineering and biotechnology · 2019
    Review
  17. Expanding lysine industry: industrial biomanufacturing of lysine and its derivatives.Journal of industrial microbiology & biotechnology · 2018
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ahmed ZahoorGenetics of Prokaryotes, Faculty of Biology & CeBiTec, University of Bielefeld, 33615 Bielefeld, Germany.
Steffen N LindnerGenetics of Prokaryotes, Faculty of Biology & CeBiTec, University of Bielefeld, 33615 Bielefeld, Germany.
Volker F WendischGenetics of Prokaryotes, Faculty of Biology & CeBiTec, University of Bielefeld, 33615 Bielefeld, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corynebacterium glutamicum is well known as the amino acid-producing workhorse of fermentation industry, being used for multi-million-ton scale production of glutamate and lysine for more than 60 years. However, it is only recently that extensive research has focused on engineering it beyond the scope of amino acids. Meanwhile, a variety of corynebacterial strains allows access to alternative carbon sources and/or allows production of a wide range of industrially relevant compounds. Some of these efforts set new standards in terms of titers and productivities achieved whereas others represent a proof-of-principle. These achievements manifest the position of C. glutamicum as an important industrial microorganism with capabilities far beyond the traditional amino acid production. In this review we focus on the state of the art of metabolic engineering of C. glutamicum for utilization of alternative carbon sources, (e.g. coming from wastes and unprocessed sources), and construction of C. glutamicum strains for production of new products such as diamines, organic acids and alcohols.

Indexed as

amino acidsdiaminesglycerolhemicelluloseorganic acids

Identifiers

PMID24688664
PMCPMC3962153

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.