ReviewComputational and structural biotechnology journal2012
Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview.
Review in Computational and structural biotechnology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- seq2ribo: structure-aware integration of machine learning and simulation to predict ribosome location profiles from RNA sequences.Bioinformatics (Oxford, England) · 2026Article
- seq2ribo: Structure-aware integration of machine learning and simulation to predict ribosome location profiles from RNA sequences.bioRxiv : the preprint server for biology · 2026Article
- Negative feedback and oscillations in a model for mRNA translation.Journal of the Royal Society, Interface · 2025Article
- Article
- Identification and Characterization of the RNA Modifying Factors PUS7 and WTAP as Key Components for the Control of Tumor Biological Processes in Renal Cell Carcinomas.Current issues in molecular biology · 2025Article
- Reversing the relative time courses of the peptide bond reaction with oligopeptides of different lengths and charged amino acid distributions in the ribosome exit tunnel.Computational and structural biotechnology journal · 2024Article
- Understanding the regulation of protein synthesis under stress conditions.Biophysical journal · 2024Article
- Ribosomal computing: implementation of the computational method.BMC bioinformatics · 2024Article
- Disruption of tRNA biogenesis enhances proteostatic resilience, improves later-life health, and promotes longevity.PLoS biology · 2024Article
- Decomposing bulk signals to reveal hidden information in processive enzyme reactions: A case study in mRNA translation.PLoS computational biology · 2024Article
- Optimization of ribosome utilization inPNAS nexus · 2023Article
- Persistence and stability of generalized ribosome flow models with time-varying transition rates.PloS one · 2023Article
- Global and gene-specific translational regulation in Escherichia coli across different conditions.PLoS computational biology · 2022Article
- A theoretical framework to analyse the flow of particles in a dynamical system with stochastic transition rates and site capacities.Royal Society open science · 2022Article
- Ribosome-Directed Therapies in Cancer.Biomedicines · 2022Review
- Large-scale mRNA translation and the intricate effects of competition for the finite pool of ribosomes.Journal of the Royal Society, Interface · 2022Article
- Article
- Accelerating Whole-Cell Simulations of mRNA Translation Using a Dedicated Hardware.ACS synthetic biology · 2021Article
- Article
- Variability in mRNA translation: a random matrix theory approach.Scientific reports · 2021Article
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1 author.
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No grant is acknowledged in the PubMed record.
Abstract
Translation or protein synthesis consists of a complex system of chemical reactions, which ultimately result in decoding of the mRNA and the production of a protein. The complexity of this reaction system makes it difficult to quantitatively connect its input parameters (such as translation factor or ribosome concentrations, codon composition of the mRNA, or energy availability) to output parameters (such as protein synthesis rates or ribosome densities on mRNAs). Mathematical and computational models of translation have now been used for nearly five decades to investigate translation, and to shed light on the relationship between the different reactions in the system. This review gives an overview over the principal approaches used in the modelling efforts, and summarises some of the major findings that were made.
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