ReviewThe Journal of clinical and aesthetic dermatology2014
Polypodium leucotomos as an Adjunct Treatment of Pigmentary Disorders.
Review in The Journal of clinical and aesthetic dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Melasma Treatment: An Evidence-Based Review.American journal of clinical dermatology · 2020Pooled it
- Beyond Melanin: A Literature Review of Photoprotection Mechanisms and Gaps in Skin of Color.Cureus · 2026Review
- Vitiligo Exchange: An Expert Panel Discussion of Two Clinical Cases.The Journal of clinical and aesthetic dermatology · 2024Article
- Update on Melasma Treatments.Annals of dermatology · 2024Review
- Management of Melasma: Laser and Other Therapies-Review Study.Journal of clinical medicine · 2024Review
- Review on photoprotection: a clinician's guide to the ingredients, characteristics, adverse effects, and disease-specific benefits of chemical and physical sunscreen compounds.Archives of dermatological research · 2023Review
- Uses ofJournal of clinical medicine · 2023Article
- Dietary Supplements and the Skin: Focus on Photoprotection and Antioxidant Activity-A Review.Nutrients · 2022Review
- Dermatologic Applications ofThe Journal of clinical and aesthetic dermatology · 2021Review
- Nonprescription acne vulgaris treatments: Their role in our treatment armamentarium-An international panel discussion.Journal of cosmetic dermatology · 2020Review
- New oral and topical approaches for the treatment of melasma.International journal of women's dermatology · 2019Article
- Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness ofThe Journal of clinical and aesthetic dermatology · 2018Article
- Herbal Compounds for the Treatment of Vitiligo: A Review.Open access Macedonian journal of medical sciences · 2018Review
- Phytochemicals from fern species: potential for medicine applications.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2017Article
- Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review.International journal of molecular sciences · 2016Review
- Use of Polypodium leucotomas Extract in Clinical Practice: A Primer for the Clinician.The Journal of clinical and aesthetic dermatology · 2016Review
- Diet in Dermatology: Review of Diet's Influence on the Conditions of Rosacea, Hidradenitis Suppurativa, Herpes Labialis, and Vitiligo.American journal of lifestyle medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionExtracts of the tropical fern Polypodium leucotomos appear to possess beneficial properties for the skin attributed to the presence of numerous compounds within the extract that have antioxidant and photoprotective properties. Orally administered Polypodium leucotomos may provide protection against the detrimental photoaging effects of sunlight and can also help reduce the frequency and severity of polymorphous light eruption. Polypodium leucotomos has also been shown to be beneficial for the prevention and potential treatment of several aesthetically relevant conditions.
objectiveThe purpose of this review is to investigate the beneficial role of Polypodium leucotomos as an adjunct treatment for vitiligo, melasma, and postinflammatory hyperpigmentation.
resultsBased on a review of relevant literature including the results of a randomized, placebo-controlled study, the oral administration of Polypodium leucotomos significantly improved the severity of melasma in women after 12 weeks. Three randomized, double-blind, placebo-controlled studies have demonstrated significant improvements in vitiligo when oral Polypodium leucotomos therapy was combined with psoralens plus ultraviolet A and narrowband ultraviolet B. No controlled studies have assessed the efficacy of Polypodium leucotomos for the treatment of postinflammatory hyperpigmentation; however, its known antioxidant and anti-inflammatory properties and demonstrated effectiveness for melasma support its use for treating this condition. No adverse events have been associated with the use of Polypodium leucotomos.
conclusionIn addition to preventing many harmful effects associated with sunlight exposure, orally administered Polypodium leucotomos also appears to provide adjunctive benefits in treating vitiligo, melasma, and may have the potential to help with postinflammatory hyperpigmentation.
Identifiers
24688621PMC3970827W1484285576What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.