ReviewFrontiers in physiology2014
Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
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110 citing papers in PubMed, 202 citations in OpenAlex.
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- Demystifying Plasmodium development within the Anopheles mosquito.Current opinion in microbiology · 2026Review
- From flower buds to bolls: how cotton reproductive structures shape boll weevil development, reproduction and survival.Pest management science · 2026Article
- Dual functions of the Aedes aegypti ecdysone receptor in dengue virus replication and reproduction control.Parasites & vectors · 2026Article
- Article
- Phytol from Sphaeranthus indicus: A Natural Insecticide Against Aedes aegypti and Culex quinquefasciatus.Acta parasitologica · 2026Article
- Lipids in Insect Reproduction: Where, How, and Why.Advances in experimental medicine and biology · 2026Review
- Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair.Immunity & ageing : I & A · 2025Article
- Juvenile hormone induces phosphorylation of insulin/insulin-like growth factor signaling proteins in previtellogenic Aedes aegypti mosquitoes.Insect science · 2025Article
- Temporal changes in amino acid profiles coordinate mosquito physiology and egg maturation in Aedes aegypti.BMC biology · 2025Article
- In silico prediction of the binding structure between vitellogenin and vitellogenin receptor of Haemaphysalis longicornis.The Journal of veterinary medical science · 2025Article
- Avian malaria and the overlooked metabolic pathways underlying mosquitoRoyal Society open science · 2025Article
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- Effects of Trehalase on the Gene Expression of the Reproductive Regulation Pathway Network and Triglyceride Metabolism inInsects · 2025Article
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- Small mosquitoes: large implications-effects of larval crowding and starvation on locomotor activity, adult biting frequency, and insecticide resistance in two strains of Aedes aegypti.Parasites & vectors · 2025Article
- Reproduction and Wing Differentiation of Gynoparae Are Regulated by Juvenile Hormone Signaling inInsects · 2025Article
- Culex quinquefasciatus Mosquitoes Exposed to a Juvenile Hormone Analog may Take a Bloodmeal While Gravid.Archives of insect biochemistry and physiology · 2025Article
- Anopheles mosquito fauna, blood meal sources and transmission intensity from high and moderate malaria endemic areas of Ethiopia.Scientific reports · 2025Article
50 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Anautogenous mosquito females require a meal of vertebrate blood in order to initiate the production of yolk protein precursors by the fat body. Yolk protein precursor gene expression is tightly repressed in a state-of-arrest before blood meal-related signals activate it and expression levels rise rapidly. The best understood example of yolk protein precursor gene regulation is the vitellogenin-A gene (vg) of the yellow fever mosquito Aedes aegypti. Vg-A is regulated by (1) juvenile hormone signaling, (2) the ecdysone-signaling cascade, (3) the nutrient sensitive target-of-rapamycin signaling pathway, and (4) the insulin-like peptide (ILP) signaling pathway. A plethora of new studies have refined our understanding of the regulation of yolk protein precursor genes since the last review on this topic in 2005 (Attardo et al., 2005). This review summarizes the role of these four signaling pathways in the regulation of vg-A and focuses upon new findings regarding the interplay between them on an organismal level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.