ArticleFrontiers in neural circuits2014
Ventral tegmental area activation promotes firing precision and strength through circuit inhibition in the primary auditory cortex.
Article in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Developmental auditory exposure shapes responses of catecholaminergic neurons to socially-modulated song.Scientific reports · 2018Article
- Article
- Frequency selectivity of echo responses in the mouse primary auditory cortex.Scientific reports · 2018Article
- Article
- Functional imaging of neuronal activity of auditory cortex by using Cal-520 in anesthetized and awake mice.Biomedical optics express · 2017Article
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7 authors at 1 institution in 1 country.
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Abstract
The activation of the ventral tegmental area (VTA) can rebuild the tonotopic representation in the primary auditory cortex (A1), but the cellular mechanisms remain largely unknown. Here, we investigated the firing patterns and membrane potential dynamics of neurons in A1 under the influence of VTA activation using in vivo intracellular recording. We found that VTA activation can significantly reduce the variability of sound evoked responses and promote the firing precision and strength of A1 neurons. Furthermore, the compressed response window was caused by an early hyperpolarization as a result of enhanced circuit inhibition. Our study suggested a possible mechanism of how the reward system affects information processing in sensory cortex: VTA activation strengthens cortical inhibition, which shortens the response window of post-synaptic cortical neurons and further promotes the precision and strength of neuronal activity.
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