ArticleInternational journal of medical sciences2014
Increased levels of circulating advanced glycation end-products in menopausal women with osteoporosis.
Article in International journal of medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06813261 (A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Pilot Trial Investigating the Impact of a Glycation Lowering), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Pilot Trial Investigating the Impact of a Glycation Lowering (GLYLO) Supplement on Geroscience Outcomes in Postmenopausal Women
Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Trial
- Carbonyl stress markers are associated with binge-eating/purging behavior of anorexia nervosa: A pilot study.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Reduction of glycation stress as a geroscience intervention: protocol for a pilot RCT in postmenopausal women.npj aging · 2026Article
- Association of plasma levels of protein-bound advanced glycation end-products and their soluble receptors with bone mineral status in young girls with the restrictive type of anorexia nervosa.Archives of osteoporosis · 2025Article
- Weight-adjusted waist index is associated with risk of poor bone quality rather than low bone mass in patients with type 2 diabetes.Diabetology & metabolic syndrome · 2025Article
- Association between prealbumin levels and the risk of osteoporosis among individuals aged 50 and above in Southwest China: a retrospective case-control study.Frontiers in medicine · 2025Article
- Association between serum 25-hydroxyvitamin D and fasting blood glucose in osteoporosis patients.Scientific reports · 2023Article
- Molecular and Cellular Mechanisms of Osteoporosis.International journal of molecular sciences · 2023Review
- The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD.Journal of clinical medicine · 2023Review
- Is Adynamic Bone Always a Disease? Lessons from Patients with Chronic Kidney Disease.Journal of clinical medicine · 2022Review
- Clinical Characteristics of Elderly People with Osteoporotic Vertebral Compression Fracture Based on a 12-Year Single-Center Experience in Korea.Geriatrics (Basel, Switzerland) · 2022Article
- Advanced glycation end products promote osteoporosis by inducing ferroptosis in osteoblasts.Molecular medicine reports · 2022Article
- Lens Autofluorescence Based Advanced Glycation End Products (AGEs) Measurement to Assess Risk of Osteopenia Among Individuals Under the Age of 50.Medical devices (Auckland, N.Z.) · 2022Article
- The role of advanced glycation end products in fracture risk assessment in postmenopausal type 2 diabetic patients.Frontiers in endocrinology · 2022Article
- Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis.Redox biology · 2021Article
- Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers.Scientific reports · 2020Article
- Deciphering the Relevance of Bone ECM Signaling.Cells · 2020Review
- Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort.BMC geriatrics · 2019Article
- Diabetes and bone.Osteoporosis and sarcopenia · 2019Review
- Blockade of receptors of advanced glycation end products ameliorates diabetic osteogenesis of adipose-derived stem cells through DNA methylation and Wnt signalling pathway.Cell proliferation · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvanced glycation end-products (AGEs) can accumulate in organs and tissues during ageing and diabetes. Increased levels of AGEs are found in the bone tissue of patients with osteoporosis. The purpose of this study was to evaluate circulating AGEs in patients with osteoporosis.
methodsWe evaluated plasma AGEs, osteoporosis-related biomarkers, and bone mass in 82 menopausal women with osteoporosis or osteopenia, 16 young women with osteopenia, and 43 healthy women without osteoporosis or osteopenia.
resultsHigher levels of serum AGEs were found in the osteoporosis or osteopenia group compared to healthy women (P < 0.0001). A negative correlation was observed between serum AGEs and lumbar spine bone density (BMD of lumbar spine, r = -0.249, P = 0.028; T-score of lumbar spine, r = -0.261, P = 0.021). Women with a increased level of serum AGEs (> 8.12 U/mL) had a 5.34-fold risk of osteopenia regarding lumbar spine T-score and a 3.31-fold risk of osteopenia regarding the hip T-score.
conclusionSerum AGEs could be used to monitor the severity and progression of osteoporosis. An increased serum level of AGEs was associated with impaired bone formation and was a risk factor for the development of osteoporosis. Targeting AGEs may represent a novel therapeutic approach for primary or secondary osteoporosis.
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