ArticleJournal of clinical biochemistry and nutrition2014
Reactive oxygen species involved cancer cellular specific 5-aminolevulinic acid uptake in gastric epithelial cells.
Article in Journal of clinical biochemistry and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Heme-porphyrin metabolism in photodynamic therapy associated with reactive oxygen species.Journal of clinical biochemistry and nutrition · 2026Article
- Reactive oxygen species induced by indomethacin enhance accumulation of heme carrier protein 1 and hematoporphyrin accumulationJournal of clinical biochemistry and nutrition · 2024Article
- Enhancement of cytotoxic effects with ALA-PDT on treatment of radioresistant cancer cells.Journal of clinical biochemistry and nutrition · 2024Article
- 5-Aminolevulinic acid improves chicken sperm motility.Animal bioscience · 2021Article
- The Cytotoxicity of Doxorubicin Can Be Accelerated by a Combination of Hyperthermia and 5-Aminolevulinic Acid.Antioxidants (Basel, Switzerland) · 2021Article
- 5-Aminolevulinic acid induced apoptosis via oxidative stress in normal gastric epithelial cells.Journal of clinical biochemistry and nutrition · 2019Article
- Article
- Acetic acid is an oxidative stressor in gastric cancer cells.Journal of clinical biochemistry and nutrition · 2018Article
- Cancer cell-specific mitochondrial reactive oxygen species promote non-heme iron uptake and enhance the proliferation of gastric epithelial cancer cell.Journal of clinical biochemistry and nutrition · 2017Article
- Mitochondrial Reactive Oxygen Species and Photodynamic Therapy.Laser therapy · 2016Article
- Reactive oxygen species induced by non-steroidal anti-inflammatory drugs enhance the effects of photodynamic therapy in gastric cancer cells.Journal of clinical biochemistry and nutrition · 2016Article
- Clinical applications of 5-aminolevulinic acid-mediated fluorescence for gastric cancer.World journal of gastroenterology · 2015Review
- Mitochondrial reactive oxygen species accelerate the expression of heme carrier protein 1 and enhance photodynamic cancer therapy effect.Journal of clinical biochemistry and nutrition · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photodynamic therapy and photodynamic diagnosis using 5-aminolevulinic acid (ALA) are clinically useful for cancer treatments. Cancer cells have been reported that 5-aminolevulinic acid is incorporated via peptide transporter 1, which is one of the membrane transport proteins, and has been reported to be significantly expressed in various gastrointestinal cancer cells such as Caco-2. However, the mechanism of this protein expression has not been elucidated. Concentration of reactive oxygen species (ROS) is higher in cancer cells in comparison with that of normal cells. We have previously reported that ROS derived from mitochondria is likely related to invasions and proliferations of cancer cells. Since 5-aminolevulinic acid is the most important precursor of heme which is necessary protein for cellular proliferations, mitochondrial ROS (mitROS) may be also related to peptide transporter 1 expressions. In this study, we used a rat gastric mucosal cell line RGM1 and its cancer-like mutated cell line RGK1, and we clarified the ALA uptake mechanism and its relations between mitROS and peptide transporter 1 expression in RGK1. We also used our self-established stable clone of cell which over-expresses manganese superoxide dismutase, a mitROS scavenger. We studied differences of the photodynamic therapy effects in these cells after ALA administrations to clear the influence of mitROS.
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