Trial reportSleep2014
Treatment of obstructive sleep apnea alters cancer-associated transcriptional signatures in circulating leukocytes.
Trial report in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- [Research Advances in Obstructive Sleep Apnea and Lung Cancer Comorbidity].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026Review
- Rationally Designed Dual Kinase Inhibitors for Management of Obstructive Sleep Apnea-A Computational Study.Biomedicines · 2026Article
- Sleep and Cancer.Cancers · 2025Review
- A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options.Frontiers in immunology · 2024Review
- Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome.Signal transduction and targeted therapy · 2023Review
- Potential Pathophysiological Pathways in the Complex Relationships between OSA and Cancer.Cancers · 2023Review
- An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling.Communications biology · 2023Article
- Sleep apnoea and incident malignancy in type 2 diabetes.ERJ open research · 2021Article
- Article
- Obstructive Sleep Apnea and Incident Cancer: A Large Retrospective Multicenter Clinical Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Sleep Apnoea Adverse Effects on Cancer: True, False, or Too Many Confounders?International journal of molecular sciences · 2020Review
- Obesity, sleep apnea, and cancer.International journal of obesity (2005) · 2020Review
- Obstructive sleep apnea and CPAP therapy alter distinct transcriptional programs in subcutaneous fat tissue.Sleep · 2020Article
- Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy.EBioMedicine · 2020Article
- Five-year relative survival in sleep apnea patients with a subsequent cancer diagnosis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Cancer and Sleep Apnea: Cutaneous Melanoma as a Case Study.American journal of respiratory and critical care medicine · 2019Review
- OSA and Cardiovascular Risk in Pediatrics.Chest · 2019Review
- Effects of CPAP on the transcriptional signatures in patients with obstructive sleep apnea via coexpression network analysis.Journal of cellular biochemistry · 2019Article
- Sleep apnea and subsequent cancer incidence.Cancer causes & control : CCC · 2018Article
- The genetics of obstructive sleep apnoea.Respirology (Carlton, Vic.) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
rationaleObstructive sleep apnea (OSA) has been associated with a number of chronic disorders that may improve with effective therapy. However, the molecular pathways affected by continuous positive airway pressure (CPAP) treatment are largely unknown. We sought to assess the system-wide consequences of CPAP therapy by transcriptionally profiling peripheral blood leukocytes (PBLs).
methodsSubjects in whom severe OSA was diagnosed were treated with CPAP, and whole-genome expression measurement of PBLs was performed at baseline and following therapy. We used gene set enrichment analysis (GSEA) to identify pathways that were differentially enriched. Network analysis was then applied to highlight key drivers of processes influenced by CPAP.
resultsEighteen subjects with significant OSA underwent CPAP therapy and microarray analysis of their PBLs. Treatment with CPAP improved apnea-hypopnea index (AHI), daytime sleepiness, and blood pressure, but did not affect anthropometric measures. GSEA revealed a number of enriched gene sets, many of which were involved in neoplastic processes and displayed downregulated expression patterns in response to CPAP. Network analysis identified several densely connected genes that are important modulators of cancer and tumor growth.
conclusionsEffective therapy of OSA with CPAP is associated with alterations in circulating leukocyte gene expression. Functional enrichment and network analyses highlighted transcriptional suppression in cancer-related pathways, suggesting potentially novel mechanisms linking OSA with neoplastic signatures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.