Evidence map›Paper›PMID 24688116›Full record

SynthesisHuman molecular genetics2014

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Joris Deelen, Marian Beekman, Hae-Won Uh, Linda Broer, Kristin L Ayers, Qihua Tan, Yoichiro Kamatani, Anna M Bennet, Riin Tamm, Stella Trompet and 77 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human molecular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 7 pooled it
23.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 7 syntheses or guidelines pooled it, 270 citations in OpenAlex.

  1. Pooled it
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  6. Limitations and risks of meta-analyses of longevity studies.Mechanisms of ageing and development · 2017
    Pooled it
  7. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015
    Pooled it
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90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

87 authors at 20 institutions in 15 countries.

Joris DeelenDepartment of Molecular Epidemiology, Netherlands Consortium for Healthy Ageing.
Marian BeekmanDepartment of Molecular Epidemiology, Netherlands Consortium for Healthy Ageing.
Hae-Won UhDepartment of Medical Statistics and Bioinformatics.
Linda BroerNetherlands Consortium for Healthy Ageing, Department of Epidemiology and.
Kristin L AyersInstitute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
Qihua TanEpidemiology, Institute of Public Health and Department of Clinical Genetics and.
Yoichiro KamataniFondation Jean Dausset-CEPH, Paris 75010, France.
Anna M BennetDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE-171 77, Sweden.
Riin TammEstonian Genome Center and Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
Stella TrompetDepartment of Cardiology and Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Daníel F GuðbjartssonPopulation Genomics, deCODE Genetics, Reykjavík 101, Iceland.
Friederike FlachsbartInstitute of Clinical Molecular Biology and.
Giuseppina RoseDepartment of Biology, Ecology and Earth Science, University of Calabria, Rende 87036, Italy.
Alexander ViktorinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE-171 77, Sweden.
Krista FischerEstonian Genome Center and.
Marianne NygaardEpidemiology, Institute of Public Health and Department of Clinical Genetics and.
Heather J CordellInstitute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
Paolina CroccoDepartment of Biology, Ecology and Earth Science, University of Calabria, Rende 87036, Italy.
Erik B van den AkkerDepartment of Molecular Epidemiology, Delft Bioinformatics Lab, Delft University of Technology, Delft 2600 GA, The Netherlands.
Stefan BöhringerDepartment of Medical Statistics and Bioinformatics.
Quinta HelmerDepartment of Medical Statistics and Bioinformatics.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
Gary I SaundersHuman and Vertebrate Analysis and Annotation, The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Maris AlverEstonian Genome Center and Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
Karen Andersen-RanbergEpidemiology, Institute of Public Health and.
Marie E BreenSchool of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Belfast BT9 7BL, UK Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
Ruud van der BreggenDepartment of Molecular Epidemiology.
Amke CaliebeInstitute of Medical Informatics and Statistics, Christian-Albrechts-University, Kiel 24105, Germany.
Miriam CapriDepartment of Experimental, Diagnostic and Specialty Medicine and.
Elisa CeveniniDepartment of Experimental, Diagnostic and Specialty Medicine and.
Joanna C CollertonInstitute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
Serena DatoDepartment of Biology, Ecology and Earth Science, University of Calabria, Rende 87036, Italy.
Karen DaviesInstitute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
Ian FordRobertson Center for Biostatistics and.
Jutta GampeLaboratory of Statistical Demography, Max Planck Institute for Demographic Research, Rostock 18057, Germany.
Paolo GaragnaniDepartment of Experimental, Diagnostic and Specialty Medicine and.
Eco J C de GeusDepartment of Biological Psychology, VU University Amsterdam, Amsterdam 1081 BT, The Netherlands EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam 1081 BT, The Netherlands.
Jennifer HarrowHuman and Vertebrate Analysis and Annotation, The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Diana van HeemstDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Bastiaan T HeijmansDepartment of Molecular Epidemiology, Netherlands Consortium for Healthy Ageing.
Femke-Anouska HeinsenInstitute of Clinical Molecular Biology and.
Jouke-Jan HottengaDepartment of Biological Psychology, VU University Amsterdam, Amsterdam 1081 BT, The Netherlands.
Albert HofmanNetherlands Consortium for Healthy Ageing, Department of Epidemiology and.
Bernard JeuneEpidemiology, Institute of Public Health and.
Palmi V JonssonGeriatrics, Landspitali University Hospital, Reykjavik 101, Iceland Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
Mark LathropFondation Jean Dausset-CEPH, Paris 75010, France EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam 1081 BT, The Netherlands McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada H3A 1A4.
Doris LechnerInstitut de Génomique, CEA, Évry 91057, France.
Carmen Martin-RuizInstitute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
Susan E McnerlanSchool of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Belfast BT9 7BL, UK Cytogenetics Laboratory, Belfast Health and Social Care Trust, Belfast BT8 8BH, UK.
Evelin MihailovEstonian Genome Center and Estonian Biocentre, Tartu 51010, Estonia.
Alberto MontesantoDepartment of Biology, Ecology and Earth Science, University of Calabria, Rende 87036, Italy.
Simon P MooijaartNetherlands Consortium for Healthy Ageing, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Anne MurphySchool of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Belfast BT9 7BL, UK.
Ellen A NohrSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus C DK-8000, Denmark Department of Gynecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, Odense C DK-5000, Denmark.
Lavinia PaternosterMRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Iris PostmusNetherlands Consortium for Healthy Ageing, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Fernando RivadeneiraNetherlands Consortium for Healthy Ageing, Department of Epidemiology and Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
Owen A RossSchool of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Belfast BT9 7BL, UK Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Stefano SalvioliDepartment of Experimental, Diagnostic and Specialty Medicine and.
Naveed SattarBHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University of Glasgow, Glasgow G12 8TA, UK.
Stefan SchreiberInstitute of Clinical Molecular Biology and PopGen Biobank, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel 24105, Germany.
Hreinn StefánssonPopulation Genomics, deCODE Genetics, Reykjavík 101, Iceland.
David J StottInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Henning TiemeierNetherlands Consortium for Healthy Ageing, Department of Epidemiology and Department of Child and Adolescent Psychiatry, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam 3000 CA, The Netherlands.
André G UitterlindenNetherlands Consortium for Healthy Ageing, Department of Epidemiology and Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
Rudi G J WestendorpNetherlands Consortium for Healthy Ageing, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Gonneke WillemsenDepartment of Biological Psychology, VU University Amsterdam, Amsterdam 1081 BT, The Netherlands.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
Pilar GalanUniversité Sorbonne Paris Cité-UREN (Unité de Recherche en Epidémiologie Nutritionnelle), U557 Inserm; U1125 Inra; Cnam; Université Paris 13, CRNH IdF, Bobigny 93017, France.
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark Institute of Preventive Medicine, Bispebjerg and Frederiksberg University Hospitals, Frederiksberg DK-2000, Denmark.
Dorret I BoomsmaDepartment of Biological Psychology, VU University Amsterdam, Amsterdam 1081 BT, The Netherlands.
J Wouter JukemaDepartment of Cardiology and Interuniversity Cardiology Institute of the Netherlands, Utrecht 3501 DG, The Netherlands.
Irene Maeve ReaSchool of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Belfast BT9 7BL, UK.
Giuseppe PassarinoDepartment of Biology, Ecology and Earth Science, University of Calabria, Rende 87036, Italy.
Anton J M de CraenDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Kaare ChristensenEpidemiology, Institute of Public Health and Department of Clinical Genetics and Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense C DK-5000, Denmark.
Almut NebelInstitute of Clinical Molecular Biology and.
Kári StefánssonPopulation Genomics, deCODE Genetics, Reykjavík 101, Iceland.
Andres MetspaluEstonian Genome Center and Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia Estonian Biocentre, Tartu 51010, Estonia.
Patrik MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE-171 77, Sweden.
Hélène BlanchéFondation Jean Dausset-CEPH, Paris 75010, France.
Lene ChristiansenEpidemiology, Institute of Public Health and Department of Clinical Genetics and.
Thomas B L KirkwoodInstitute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
Cornelia M van DuijnNetherlands Consortium for Healthy Ageing, Department of Epidemiology and.
Claudio FranceschiDepartment of Experimental, Diagnostic and Specialty Medicine and Interdepartmental Centre 'L. Galvani', University of Bologna, Bologna 40126, Italy IRCCS Institute of Neurological Science, Bellaria Hospital, Bologna 40139, Italy CNR-ISOF, Bologna 40129, Italy.
Jeanine J Houwing-DuistermaatDepartment of Medical Statistics and Bioinformatics.
P Eline SlagboomDepartment of Molecular Epidemiology, Netherlands Consortium for Healthy Ageing, p.slagboom@lumc.nl.
Netherlands Consortium for Healthy Ageing · NLLeiden University Medical Center · NLInstitute of Public Health Bengaluru · INNew York Genome Center · USQueen's University Belfast · GBUniversity of Calabria · ITNewcastle Hospitals - Campus for Ageing and Vitality · GBdeCODE Genetics (Iceland) · ISFondation Jean Dausset-CEPH · FRInstitute of Molecular Biology · BGKarolinska Institutet · SEVrije Universiteit Amsterdam · NLCentre for Life · GBChristian-Albrechts-Universität zu Kiel · DEErasmus MC · NLUniversity of Glasgow · GBUniversity of Leicester · GBWellcome Sanger Institute · GBAmsterdam Public Health · NLCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FR

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
GENCODE Resource ProjectU41HG007234 · NHGRI · SANGER INSTITUTE · PI FLICEK, PAUL · 2013 to 2020
$20.3M
TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI YASHIN, ANATOLIY I · 1990 to 2008
$17.5M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie A Arboleda, Harold Pimentel · 2002 to 2026
$8.6M
Interstitial Cystitis in Swedish TwinsU01DK066134 · NIDDK · KAROLINSKA INSTITUTE · PI PEDERSEN, NANCY L · 2004 to 2008
$2.9M
Major Depression: Stage 1 Genomewide Association in Population-Based SamplesR01MH081802 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2007 to 2007
$138k
Biotechnology and Biological Sciences Research Council BB/F010966/1Biotechnology and Biological Sciences Research Council BB/I020748/1European Research Council 230374Medical Research Council G0500997Medical Research Council G0601333Medical Research Council MR/J012165/1Medical Research Council MR/J50001X/1Medical Research Council MR/K006312/1NHGRI NIH HHS T32 HG002536NHGRI NIH HHS U41 HG007234NIA NIH HHS P01 AG008761NIA NIH HHS P01AG08761NIDDK NIH HHS U01 DK066134NIDDK NIH HHS U01DK066134NIMH NIH HHS MH081802NIMH NIH HHS R01 MH081802NIMH NIH HHS U24 MH068457PHS HHS NIMH U24 MH068457-06PHS HHS R01D0042157-01AThe Dunhill Medical Trust R124/0509Wellcome TrustWellcome Trust 084762Wellcome Trust 085475Wellcome Trust 087436
6 · The paper itself

Abstract

The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥ 85 years) and 16 121 younger controls (<65 years) followed by replication in an additional set of 13 060 long-lived individuals and 61 156 controls. In addition, we performed a subset analysis in cases aged ≥ 90 years. We observed genome-wide significant association with longevity, as reflected by survival to ages beyond 90 years, at a novel locus, rs2149954, on chromosome 5q33.3 (OR = 1.10, P = 1.74 × 10(-8)). We also confirmed association of rs4420638 on chromosome 19q13.32 (OR = 0.72, P = 3.40 × 10(-36)), representing the TOMM40/APOE/APOC1 locus. In a prospective meta-analysis (n = 34 103), the minor allele of rs2149954 (T) on chromosome 5q33.3 associates with increased survival (HR = 0.95, P = 0.003). This allele has previously been reported to associate with low blood pressure in middle age. Interestingly, the minor allele (T) associates with decreased cardiovascular mortality risk, independent of blood pressure. We report on the first GWAS-identified longevity locus on chromosome 5q33.3 influencing survival in the general European population. The minor allele of this locus associates with low blood pressure in middle age, although the contribution of this allele to survival may be less dependent on blood pressure. Hence, the pleiotropic mechanisms by which this intragenic variation contributes to lifespan regulation have to be elucidated.

Indexed as

AgedAged, 80 and overAge FactorsCardiovascular DiseasesChromosome MappingChromosomes, Human, Pair 19Chromosomes, Human, Pair 5FemaleGenetic LociGenome-Wide Association StudyHumansHypertensionLongevityMalePhenotypeProspective Studies

Identifiers

PMID24688116
PMCPMC4103672
OpenAlexW2168300179

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.