ArticleThe Journal of infectious diseases2014
Elevated brain monoamine oxidase activity in SIV- and HIV-associated neurological disease.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
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- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
- Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Dengue Virus Replication Is Associated with Catecholamine Biosynthesis and Metabolism in Hepatocytes.Viruses · 2022Article
- Association of Hepatitis C Virus Replication with the Catecholamine Biosynthetic Pathway.Viruses · 2021Article
- In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage.Redox biology · 2020Article
- Upregulation of Superoxide Dismutase 2 by Astrocytes in the SIV/Macaque Model of HIV-Associated Neurologic Disease.Journal of neuropathology and experimental neurology · 2020Article
- Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- SIV-Induced Immune Activation and Metabolic Alterations in the Dorsal Root Ganglia During Acute Infection.Journal of neuropathology and experimental neurology · 2019Article
- Increased Microglial CSF1R Expression in the SIV/Macaque Model of HIV CNS Disease.Journal of neuropathology and experimental neurology · 2018Article
- Frontline Science: CXCR7 mediates CD14Journal of leukocyte biology · 2017Article
- Mechanisms of CNS Viral Seeding by HIVmBio · 2017Article
- HIV, Tat and dopamine transmission.Neurobiology of disease · 2017Review
- Phytochemical Inhibition of Multidrug Resistance Protein-1 as a Therapeutic Strategy for Hemangioendothelioma.Antioxidants & redox signaling · 2017Article
- SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load.Scientific reports · 2016Article
- Δ9-Tetrahydrocannabinol (Δ9-THC) Promotes Neuroimmune-Modulatory MicroRNA Profile in Striatum of Simian Immunodeficiency Virus (SIV)-Infected Macaques.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Article
- Distinct Patterns of Tryptophan Maintenance in Tissues during Kynurenine Pathway Activation in Simian Immunodeficiency Virus-Infected Macaques.Frontiers in immunology · 2016Article
- Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.Journal of neurovirology · 2015Article
- Altered Monoamine and Acylcarnitine Metabolites in HIV-Positive and HIV-Negative Subjects With Depression.Journal of acquired immune deficiency syndromes (1999) · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We recently demonstrated direct evidence of increased monoamine oxidase (MAO) activity in the brain of a simian immunodeficiency virus (SIV) model of human immunodeficiency virus (HIV)-associated central nervous system (CNS) disease, consistent with previously reported dopamine deficits in both SIV and HIV infection. In this study, we explored potential mechanisms behind this elevated activity. MAO B messenger RNA was highest in macaques with the most severe SIV-associated CNS lesions and was positively correlated with levels of CD68 and GFAP transcripts in the striatum. MAO B messenger RNA also correlated with viral loads in the CNS of SIV-infected macaques and with oxidative stress. Furthermore, in humans, striatal MAO activity was elevated in individuals with HIV encephalitis, compared with activity in HIV-seronegative controls. These data suggest that the neuroinflammation and oxidative stress caused by SIV infection in the CNS may provide the impetus for increased transcription of MAO B and that MAO, and more broadly, oxidative stress, have significant potential as therapeutic targets in CNS disease due to HIV.
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