ArticleNucleic acids research2014
The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Pulse Dipolar Electron Paramagnetic Resonance Spectroscopy Distance Measurements at Low Nanomolar Concentrations: The CuThe journal of physical chemistry letters · 2024Article
- Comprehensive analysis of histone-binding proteins with multi-angle light scattering.Methods (San Diego, Calif.) · 2020Article
- Stoichiometry of Rtt109 complexes with Vps75 and histones H3-H4.Life science alliance · 2020Article
- The contribution of modern EPR to structural biology.Emerging topics in life sciences · 2018Article
- Sparse Labeling PELDOR Spectroscopy on Multimeric Mechanosensitive Membrane Channels.Biophysical journal · 2017Article
- Histone chaperone networks shaping chromatin function.Nature reviews. Molecular cell biology · 2017Review
- Long Distance Measurements up to 160 Å in the GroEL Tetradecamer Using Q-Band DEER EPR Spectroscopy.Angewandte Chemie (International ed. in English) · 2016Article
- Coordinated Action of Nap1 and RSC in Disassembly of Tandem Nucleosomes.Molecular and cellular biology · 2016Article
- The histone chaperone Vps75 forms multiple oligomeric assemblies capable of mediating exchange between histone H3-H4 tetramers and Asf1-H3-H4 complexes.Nucleic acids research · 2016Article
- Rotameric preferences of a protein spin label at edge-strand β-sheet sites.Protein science : a publication of the Protein Society · 2016Article
- DEER Sensitivity between Iron Centers and Nitroxides in Heme-Containing Proteins Improves Dramatically Using Broadband, High-Field EPR.The journal of physical chemistry letters · 2016Article
- Accurate Extraction of Nanometer Distances in Multimers by Pulse EPR.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- The use of the Rx spin label in orientation measurement on proteins, by EPR.Physical chemistry chemical physics : PCCP · 2016Article
- The double-histidine Cu²⁺-binding motif: a highly rigid, site-specific spin probe for electron spin resonance distance measurements.Angewandte Chemie (International ed. in English) · 2015Article
- Modelling multi-protein complexes using PELDOR distance measurements for rigid body minimisation experiments using XPLOR-NIH.Methods (San Diego, Calif.) · 2014Article
- The spatial effect of protein deuteration on nitroxide spin-label relaxation: implications for EPR distance measurement.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Article
- Origins of structural flexibility in protein-based supramolecular polymers revealed by DEER spectroscopy.The journal of physical chemistry. B · 2014Article
- Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 inSignal transduction and targeted therapyArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a characteristic homodimeric conformation. In this study, a combination of small angle X-ray scattering, multi angle light scattering and pulsed electron-electron double resonance approaches were used to show that both Vps75 and Nap1 adopt ring-shaped tetrameric conformations in solution. This suggests that the formation of homotetramers is a common feature of NAP-1 fold histone chaperones. The tetramerisation of NAP-1 fold histone chaperones may act to shield acidic surfaces in the absence of histone cargo thus providing a 'self-chaperoning' type mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.