SynthesisAmerican journal of hypertension2014
Common genetic variations in the vitamin D pathway in relation to blood pressure.
Synthesis in American journal of hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Meta-Analysis of the Association Between the rs228570 Vitamin D Receptor Gene Polymorphism and Arterial Hypertension Risk.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Vitamin DEuropean journal of nutrition · 2017Trial
- Single Nucleotide Polymorphisms in the Vitamin D Metabolic Pathway and Their Relationship with High Blood Pressure Risk.International journal of molecular sciences · 2023Article
- Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link.Clinical hypertension · 2023Review
- Association ofNutrients · 2022Article
- The Association of Vitamin D and Its Pathway Genes' Polymorphisms with Hypertensive Disorders of Pregnancy: A Prospective Cohort Study.Nutrients · 2022Article
- A Fast and Accurate Method for Genome-Wide Time-to-Event Data Analysis and Its Application to UK Biobank.American journal of human genetics · 2020Article
- Contribution of CYP24A1 variants in coronary heart disease among the Chinese population.Lipids in health and disease · 2020Article
- Vitamin D and Atherosclerotic Cardiovascular Disease.The Journal of clinical endocrinology and metabolism · 2019Article
- A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.Human molecular genetics · 2019Article
- Update on Chronic Kidney Disease Mineral and Bone Disorder in Cardiovascular Disease.Seminars in nephrology · 2018Review
- Vitamin-D concentrations, cardiovascular risk and events - a review of epidemiological evidence.Reviews in endocrine & metabolic disorders · 2017Review
- Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure.PLoS genetics · 2017Article
- Article
- Exome sequencing in pooled DNA samples to identify maternal pre-eclampsia risk variants.Scientific reports · 2016Article
- Vitamin D and cardiovascular disease prevention.Nature reviews. Cardiology · 2016Review
- Vitamin D receptor gene polymorphisms and plasma renin activity in essential hypertensive individuals.Journal of human hypertension · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundVitamin D is involved in blood pressure (BP) regulation. Genetic variations may influence the effect of vitamin D on BP, but data from epidemiologic studies remain inconsistent.
methodsWe conducted a comprehensive genetic association study in the Women's Genome Health Study (WGHS) with genome-wide genotype data among 23,294 women of European ancestry and in the International Consortium of Blood Pressure (ICBP) with genome-wide meta-analysis results from 69,395 men and women of European ancestry.
resultsFirst, we found none of 5 selected vitamin D-related candidate single nucleotide polymorphisms (SNPs) was associated with systolic BP (SBP) or diastolic BP (DBP). Second, in 61 candidate SNPs involved in vitamin D metabolism and signaling, rs1507023 (in RBFOX1) and rs2296241 (in CYP24A1) showed significant associations with SBP, DBP, mean arterial pressure, or pulse pressure in the WGHS before, but not after, multiple testing corrections. Nominally significant associations in the ICBP were also not significant after corrections. Third, among 24 candidate genes across vitamin D pathway, associations with BP traits that meet gene-wide significance level were found for NCOA3 (rs2235734), RXRA (rs875444), DHCR7 (rs1790370), VDR (rs2544037), and NCOR2 (rs1243733, rs1147289) in the WGHS and NCOR1, TP53BP1, and TYRP1 in the ICBP. However, none of these associations reached significance threshold in both studies.
conclusionsOur study did not replicate previously observed associations of vitamin D-related SNPs with BP. There was suggestive evidence for associations in other vitamin D pathway genes; however, these associations either did not reach the significance threshold or were not replicated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.