ArticleAntimicrobial agents and chemotherapy2014
Antifungal susceptibility patterns of opportunistic fungi in the genera Verruconis and Ochroconis.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Mycobiome of Stool, Blood, Thrombus and Vessel Wall in Abdominal Aortic Aneurysm Patients.Mycopathologia · 2025Article
- PulmonaryJournal of fungi (Basel, Switzerland) · 2025Article
- Recurrent Verruconis gallopava Infection at One Year after Excision of a Solitary Pulmonary Lesion.Internal medicine (Tokyo, Japan) · 2024Article
- In Vivo Evaluation of Miconazole-Nitrate-Loaded Transethosomal Gel Using a Rat Model Infected withPharmaceuticals (Basel, Switzerland) · 2024Article
- Answer to July 2023 Photo Quiz.Journal of clinical microbiology · 2023Article
- Unusual manifestation of pulmonaryBMJ case reports · 2023Article
- RE-EVALUATION OFPersoonia · 2022Article
- Posaconazole Alone and in Combination with Caspofungin for Treatment of ExperimentalJournal of fungi (Basel, Switzerland) · 2020Article
- Double invasive fungal infection due to dematiaceous moulds in a renal transplant patient.BMJ case reports · 2018Article
- Verruconis gallopava cardiac and endovascular infection with dissemination after renal transplantation: Case report and lessons learned.Medical mycology case reports · 2017Article
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- Occurrence of Ochroconis and Verruconis species in clinical specimens from the United States.Journal of clinical microbiology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Species of Verruconis and species of Ochroconis are dematiaceous fungi generally found in the environment but having the ability to infect humans, dogs, cats, poultry, and fish. This study presents the antifungal susceptibility patterns of these fungi at the species level. Forty strains originating from clinical and environmental sources were phylogenetically identified at the species level by using sequences of the ribosomal DNA internal transcribed spacer (rDNA ITS). In vitro antifungal susceptibility testing was performed against eight antifungals, using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method. The geometric mean MICs for amphotericin B (AMB), flucytosine (5FC), fluconazole (FLC), itraconazole (ITC), voriconazole (VRC), and posaconazole (POS) and minimum effective concentrations (MECs) for caspofungin (CAS) and anidulafungin (AFG) across the Ochroconis and Verruconis species were as follows, in increasing order. For Verruconis species, the values (μg/ml) were as follows: AFG, 0.04; POS, 0.25; ITC, 0.37; AMB, 0.50; CAS, 0.65; VRC, 0.96; 5FC, 10.45; and FLC, 47.25. For Ochroconis species, the values (μg/ml) were as follows: AFG, 0.06; POS, 0.11; CAS, 0.67; VRC, 2.76; ITC, 3.94; AMB, 5.68; 5FC, 34.48; and FLC, 61.33. Antifungal susceptibility of Ochroconis and Verruconis was linked with phylogenetic distance and thermotolerance. Echinocandins and POS showed the greatest in vitro activity, providing possible treatment options for Ochroconis and Verruconis infections.
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