ArticleMolecular and cellular biochemistry2014
Maslinic acid induced apoptosis in bladder cancer cells through activating p38 MAPK signaling pathway.
Article in Molecular and cellular biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- The Role of Natural Compounds in Bladder Urothelial Carcinoma Treatment.International journal of molecular sciences · 2026Review
- A Comprehensive Review of the Antitumor Activity of Olive Compounds: The Case of Olive Oil, Pomace, and Leaf Extracts, Phenolic Alcohols, Secoiridoids, and Triterpenes.Antioxidants (Basel, Switzerland) · 2025Review
- Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells.Frontiers in pharmacology · 2024Article
- Sulforaphane and bladder cancer: a potential novel antitumor compound.Frontiers in pharmacology · 2023Review
- Maslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases.Molecules (Basel, Switzerland) · 2022Review
- Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid.Drug delivery · 2022Article
- A four-miRNA signature in serum as a biomarker for bladder cancer diagnosis.American journal of translational research · 2022Article
- The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review.Drug design, development and therapy · 2021Review
- A New Ferroptosis-Related lncRNA Signature Predicts the Prognosis of Bladder Cancer Patients.Frontiers in cell and developmental biology · 2021Article
- Unveiling the Differential Antioxidant Activity of Maslinic Acid in Murine Melanoma Cells and in Rat Embryonic Healthy Cells Following Treatment with Hydrogen Peroxide.Molecules (Basel, Switzerland) · 2020Article
- Article
- Maslinic acid alleviates ischemia/reperfusion-induced inflammation by downregulation of NFκB-mediated adhesion molecule expression.Scientific reports · 2019Article
- Maslinic acid promotes autophagy by disrupting the interaction between Bcl2 and Beclin1 in rat pheochromocytoma PC12 cells.Oncotarget · 2017Article
- Article
- Maslinic Acid Inhibits Proliferation of Renal Cell Carcinoma Cell Lines and Suppresses Angiogenesis of Endothelial Cells.Journal of kidney cancer and VHL · 2017Article
- Acute and Subacute Oral Toxicity Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.Oncotarget · 2015Article
- Maslinic Acid, a Triterpene from Olive, Affects the Antioxidant and Mitochondrial Status of B16F10 Melanoma Cells Grown under Stressful Conditions.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro.Drug design, development and therapy · 2015Article
- RETRACTED: Maslinic acid induces mitochondrial apoptosis and suppresses HIF-1α expression in A549 lung cancer cells under normoxic and hypoxic conditions.Molecules (Basel, Switzerland) · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bladder cancer is among the most aggressive human malignant carcinoma and always showed resistance to traditional chemotherapy based on DNA damaging drugs. Unlike the existing drugs that damage nuclear acid molecules, maslinic acid (MA) displays anti-tumor function in various types of cancers by targeting specific intracellular signaling pathways and is regarded as a promising agent for future clinical cancer therapy. However, its effect on bladder cancer is still unknown. In this study, we assessed the influence of MA on survival of bladder cancer cells and the involved mechanisms. MTT assay showed that MA suppressed the viability of bladder cancer cells. We further confirmed the growth-suppressing activity of MA on T24 and 253J xenograft tumor in mouse models. Subsequently, we found that MA induced apoptosis in bladder cancer cells. Based on immunoblotting assay, we determined that p38 MAPK pathway was greatly activated in MA-treated bladder cancer cells. SB203580 inhibition of p38 MAPK rescued the MA-induced apoptosis of bladder cancer cells. In conclusion, we provided evidences that MA efficiently suppressed activation of p38 MAPK pathways and induced apoptosis of bladder cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.