ArticlePlanta2014
Arabidopsis Bax inhibitor-1 promotes sphingolipid synthesis during cold stress by interacting with ceramide-modifying enzymes.
Article in Planta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Dynamics of ER stress-induced gene regulation in plants.Nature reviews. Genetics · 2024Review
- Arabidopsis Leaf Chloroplasts Have a Specific Sphingolipidome.Plants (Basel, Switzerland) · 2024Article
- Sphingolipids with 2-hydroxy fatty acids aid in plasma membrane nanodomain organization and oxidative burst.Plant physiology · 2022Article
- Enhanced Adaptability to Limited Water Supply Regulated by Diethyl Aminoethyl Hexanoate (DA-6) Associated With Lipidomic Reprogramming in Two White Clover Genotypes.Frontiers in plant science · 2022Article
- Overexpression of a ceramide synthase gene,Frontiers in plant science · 2022Article
- Sphingolipid metabolism, transport, and functions in plants: Recent progress and future perspectives.Plant communications · 2021Review
- Sphingolipid Δ4-desaturation is an important metabolic step for glycosylceramide formation in Physcomitrium patens.Journal of experimental botany · 2021Article
- The dynamics and role of sphingolipids in eukaryotic organisms upon thermal adaptation.Progress in lipid research · 2020Review
- Sphingolipids: towards an integrated view of metabolism during the plant stress response.The New phytologist · 2020Review
- Fumonisin B1: A Tool for Exploring the Multiple Functions of Sphingolipids in Plants.Frontiers in plant science · 2020Review
- Plant-UniquePlants (Basel, Switzerland) · 2019Article
- PropaNet: Time-Varying Condition-Specific Transcriptional Network Construction by Network Propagation.Frontiers in plant science · 2019Article
- Arabidopsis Bax inhibitor-1 interacts with enzymes related to very-long-chain fatty acid synthesis.Journal of plant research · 2019Article
- A novel VIGS method by agroinoculation of cotton seeds and application for elucidating functions of GhBI-1 in salt-stress response.Plant cell reports · 2018Article
- Transcriptomic changes in Cucurbita pepo fruit after cold storage: differential response between two cultivars contrasting in chilling sensitivity.BMC genomics · 2018Article
- TMBIM-mediated CaBiochimica et biophysica acta. Molecular cell research · 2017Review
- Synthesis and degradation of long-chain base phosphates affect fumonisin BJournal of plant research · 2017Article
- Loss of Inositol Phosphorylceramide Sphingolipid Mannosylation Induces Plant Immune Responses and Reduces Cellulose Content in Arabidopsis.The Plant cell · 2016Article
- Genes encoding Δ(8)-sphingolipid desaturase from various plants: identification, biochemical functions, and evolution.Journal of plant research · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bax inhibitor-1 (BI-1) is a widely conserved cell death suppressor localized in the endoplasmic reticulum membrane. Our previous results revealed that Arabidopsis BI-1 (AtBI-1) interacts with not only Arabidopsis cytochrome b 5 (Cb5), an electron transfer protein, but also a Cb5-like domain (Cb5LD)-containing protein, Saccharomyces cerevisiae fatty acid 2-hydroxylase 1, which 2-hydroxylates sphingolipid fatty acids. We have now found that AtBI-1 binds Arabidopsis sphingolipid Δ8 long-chain base (LCB) desaturases AtSLD1 and AtSLD2, which are Cb5LD-containing proteins. The expression of both AtBI-1 and AtSLD1 was increased by cold exposure. However, different phenotypes were observed in response to cold treatment between an atbi-1 mutant and a sld1sld2 double mutant. To elucidate the reasons behind the difference, we analyzed sphingolipids and found that unsaturated LCBs in atbi-1 were not altered compared to wild type, whereas almost all LCBs in sld1sld2 were saturated, suggesting that AtBI-1 may not be necessary for the desaturation of LCBs. On the other hand, the sphingolipid content in wild type increased in response to low temperature, whereas total sphingolipid levels in atbi-1 were unaltered. In addition, the ceramide-modifying enzymes AtFAH1, sphingolipid base hydroxylase 2 (AtSBH2), acyl lipid desaturase 2 (AtADS2) and AtSLD1 were highly expressed under cold stress, and all are likely to be related to AtBI-1 function. These findings suggest that AtBI-1 contributes to synthesis of sphingolipids during cold stress by interacting with AtSLD1, AtFAH1, AtSBH2 and AtADS2.
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