ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
First principles of Hamiltonian medicine.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Kin selection explains the evolution of cooperation in the gut microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Defector clustering is linked to cooperation in a pathogenic bacterium.Proceedings. Biological sciences · 2017Article
- Breast cancer complexity: implications of intratumoral heterogeneity in clinical management.Cancer metastasis reviews · 2017Review
- Resource abundance and the critical transition to cooperation.Journal of evolutionary biology · 2017Article
- Harbouring public good mutants within a pathogen population can increase both fitness and virulence.eLife · 2016Article
- Within-host competitive interactions as a mechanism for the maintenance of parasite diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Tumorigenesis: it takes a village.Nature reviews. Cancer · 2015Review
- Sociality and health: impacts of sociality on disease susceptibility and transmission in animal and human societies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Research highlights for issue 5: the role of the microbiome in shaping evolution.Evolutionary applications · 2014Article
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3 authors.
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Abstract
We introduce the field of Hamiltonian medicine, which centres on the roles of genetic relatedness in human health and disease. Hamiltonian medicine represents the application of basic social-evolution theory, for interactions involving kinship, to core issues in medicine such as pathogens, cancer, optimal growth and mental illness. It encompasses three domains, which involve conflict and cooperation between: (i) microbes or cancer cells, within humans, (ii) genes expressed in humans, (iii) human individuals. A set of six core principles, based on these domains and their interfaces, serves to conceptually organize the field, and contextualize illustrative examples. The primary usefulness of Hamiltonian medicine is that, like Darwinian medicine more generally, it provides novel insights into what data will be productive to collect, to address important clinical and public health problems. Our synthesis of this nascent field is intended predominantly for evolutionary and behavioural biologists who aspire to address questions directly relevant to human health and disease.
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