ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Persistent pain facilitates response to morphine reward by downregulation of central amygdala GABAergic function.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Prevalence and associated factors of opioid-related disorders among patients with chronic pain: a single-center retrospective study in a Chinese tertiary hospital.BMC anesthesiology · 2026Article
- The pPVTThe journal of headache and pain · 2026Article
- Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seeking in male mice.Alcohol (Fayetteville, N.Y.) · 2025Article
- Interactions of pain and opioids on conditioned place preference in rodents.Psychopharmacology · 2025Review
- Chronic inflammatory pain reduces fentanyl intake during early acquisition of fentanyl self-administration, but does not change motivation to take fentanyl in male and female rats.Pharmacology, biochemistry, and behavior · 2024Article
- The effects of chronic neuropathic pain on the self-administration of highly potent MOR agonist, fentanyl.bioRxiv : the preprint server for biology · 2024Article
- An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats.Scientific reports · 2023Article
- Chronic inflammatory pain promotes place preference for fentanyl in male rats but does not change fentanyl self-administration in male and female rats.Neuropharmacology · 2023Article
- An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats.Research square · 2023Article
- Scrambler Therapy for Chronic Pain after Burns and Its Effect on the Cerebral Pain Network: A Prospective, Double-Blinded, Randomized Controlled Trial.Journal of clinical medicine · 2022Article
- Effect of electrical stimulation of central nucleus of the amygdala on morphine conditioned place preference in male rats.Iranian journal of basic medical sciences · 2022Article
- Mechanism and effects of STING-IFN-I pathway on nociception: A narrative review.Frontiers in molecular neuroscience · 2022Review
- Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward.Molecular psychiatry · 2021Article
- Factors mediating pain-related risk for opioid use disorder.Neuropharmacology · 2021Review
- Neurobiological aspects of pain in the context of alcohol use disorder.International review of neurobiology · 2021Article
- The Convergent Neuroscience of Affective Pain and Substance Use Disorder.Alcohol research : current reviews · 2021Review
- GluA1 in Central Amygdala Promotes Opioid Use and Reverses Inhibitory Effect of Pain.Neuroscience · 2020Article
- Methylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain.Anesthesia and analgesia · 2020Article
- Incisional Injury Modulates Morphine Reward and Morphine-Primed Reinstatement: A Role of Kappa Opioid Receptor Activation.Anesthesia and analgesia · 2020Article
- Concurrent and lagged associations of prescription opioid use with pain and negative affect in the daily lives of chronic pain patients.Journal of consulting and clinical psychology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Opioid-based analgesics are widely used for treating chronic pain, but opioids are highly addictive when repeatedly used because of their strong rewarding effects. In recent years, abuse of prescription opioids has dramatically increased, including incidences of misuse of opioid drugs prescribed for pain control. Despite this issue in current clinical pain management, it remains unknown how pain influences the abuse liability of prescription opioids. Pain as aversive experience may affect opioid reward of positive emotion through common brain sites involved in emotion processing. In this study, on a rat model of chronic pain, we determined how persistent pain altered behavioral responses to morphine reward measured by the paradigm of unbiased conditioned place preference (CPP), focusing on GABAergic synaptic activity in neurons of the central nucleus of the amygdala (CeA), an important brain region for emotional processing of both pain and reward. We found that pain reduced the minimum number of morphine-conditioning sessions required for inducing CPP behavior. Both pain and morphine conditioning that elicited CPP inhibited GABA synaptic transmission in CeA neurons. Pharmacological activation of CeA GABAA receptors reduced the pain and inhibited CPP induced both by an effective dose of morphine and by a sub-threshold dose of morphine under pain condition. Furthermore, inhibition of CeA GABAA receptors mimicked the pain effect, rendering the sub-threshold dose of morphine effective in CPP induction. These findings suggest that pain facilitates behavioral responses to morphine reward by predisposing the inhibitory GABA function in the CeA circuitry involved in the behavior of opioid reward.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.