Evidence map›Paper›PMID 24686741›Full record

ArticleThe American journal of tropical medicine and hygiene2014

Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978.

Chunkai Wang, Qingjie Zhao, Jaeki Min, Sakthivel Muniyan, Mireille Vargas, Xiaofang Wang, Yuxiang Dong, R Kiplin Guy, Ming-Fong Lin, Jennifer Keiser and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal.The Journal of antimicrobial chemotherapy · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Chunkai WangCollege of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland.
Qingjie ZhaoCollege of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland.
Jaeki MinCollege of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland.
Sakthivel MuniyanCollege of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland.
Mireille VargasCollege of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland.
Xiaofang WangCollege of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland.
Yuxiang DongCollege of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland.
R Kiplin GuyCollege of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland.
Ming-Fong LinCollege of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland.
Jennifer KeiserCollege of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland.
Jonathan L VennerstromCollege of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland jvenners@unmc.edu.
University of Nebraska Medical Center · US

Funding

Increasing the Antischistosomal Selectivity of Aryl HydantoinsR21AI097802 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI VENNERSTROM, JONATHAN L · 2012 to 2013
$358k
NIAID NIH HHS R21 AI097802NIAID NIH HHS R21 AI097802-02
6 · The paper itself

Abstract

In the early 1980s, the antischistosomal aryl hydantoin Ro 13-3978 (AH01), a close structural analogue of the androgen receptor antagonist nilutamide, was discovered. Administration of 100 mg/kg oral doses of AH01 to mice infected with adult and juvenile Schistosoma mansoni produced 95% and 64% total worm burden reductions, confirming its high activity against adult worms, and showing that AH01 is also effective against juvenile infections. AH01 had no measureable interaction with the androgen receptor in a ligand competition assay, but it did block dihydrotestosterone-induced cell proliferation in an androgen-dependent human prostate cancer cell line. For AH01, nilutamide, and three closely related aryl hydantoin derivatives, there was no correlation between antischistosomal activity and androgen receptor interaction.

Indexed as

Androgen Receptor AntagonistsAnimalsCell Line, TumorCell ProliferationDihydrotestosteroneDisease Models, AnimalHumansHydantoinsImidazolidinesMaleMiceSchistosoma mansoniSchistosomiasis mansoniSchistosomicidesAndrogen Receptor AntagonistsDihydrotestosteroneHydantoinsImidazolidinesnilutamideRo 13-3978Schistosomicides

Identifiers

PMID24686741
PMCPMC4047746
OpenAlexW2144743109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.