ArticleOptics letters2014
Experimental and simulation study of the wavelength dependent second harmonic generation of collagen in scattering tissues.
Article in Optics letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Generalized 3D quasi-phase-matching model of image contrast in second harmonic generation microscopy of fibrillar collagen architectures.JPhys photonics · 2026Article
- Generation of In Vivo-Inspired 3D Collagen Models for Guided Tumor Invasion In Vitro.Current protocols · 2026Article
- Nonlinear Imaging Detection of Organ Fibrosis in Minute Samples for Early Stage Utilizing Dual-Channel Two-Photon and Second-Harmonic Excitation.Biosensors · 2025Article
- SHG Fiberscopy Assessment of Collagen Morphology and Its Potential for Breast Cancer Optical Histology.IEEE transactions on bio-medical engineering · 2024Article
- Second harmonic generation microscopy: a powerful tool for bio-imaging.Biophysical reviews · 2023Review
- Nonlinear optical imaging by detection with optical parametric amplification (invited paper).Journal of innovative optical health sciences · 2023Article
- Multimodal microscopy for the simultaneous visualization of five different imaging modalities using a single light source.Biomedical optics express · 2021Article
- Examining lysyl oxidase-like modulation of collagen architecture in 3D spheroid models of idiopathic pulmonary fibrosis via second-harmonic generation microscopy.Journal of biomedical optics · 2021Article
- Label-Free Multiphoton Microscopy: Much More Than Fancy Images.International journal of molecular sciences · 2021Review
- Recent Advancements in Optical Harmonic Generation Microscopy: Applications and Perspectives.BME frontiers · 2021Review
- Second-harmonic generation microscopy analysis reveals proteoglycan decorin is necessary for proper collagen organization in prostate.Journal of biomedical optics · 2019Article
- Assessing local stromal alterations in human ovarian cancer subtypes via second harmonic generation microscopy and analysis.Journal of biomedical optics · 2017Article
- Comparison of second harmonic microscopy images of collagen-based ocular tissues with 800 and 1045 nm.Biomedical optics express · 2017Article
- A new mode of contrast in biological second harmonic generation microscopy.Scientific reports · 2017Article
- Wavelength-Dependent Second Harmonic Generation Circular Dichroism for Differentiation of Col I and Col III Isoforms in Stromal Models of Ovarian Cancer Based on Intrinsic Chirality Differences.The journal of physical chemistry. B · 2017Article
- Stromal alterations in ovarian cancers via wavelength dependent Second Harmonic Generation microscopy and optical scattering.BMC cancer · 2017Article
- Endogenous Optical Signals Reveal Changes of Elastin and Collagen Organization During Differentiation of Mouse Embryonic Stem Cells.Tissue engineering. Part C, Methods · 2015Article
- Articular cartilage zonal differentiation via 3D Second-Harmonic Generation imaging microscopy.Connective tissue research · 2015Article
- Applications of second-harmonic generation imaging microscopy in ovarian and breast cancer.Perspectives in medicinal chemistry · 2015Article
- Unified Vibrational and Multiphoton Label-Free Nonlinear Microscopy for Simultaneous Chemical and Structural Imaging.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
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5 authors.
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Abstract
We report on the wavelength dependence of second harmonic generation (SHG) of collagen in scattering tissues over the wavelength range of 800-1200 nm. The study incorporates inclusion of the molecular hyperpolarizability β of collagen and optical scattering, both of which are wavelength dependent. Using 3D SHG imaging and Monte Carlo simulations, we find the wavelength dependence of β is not well described by a two-state model based on known absorption bands. We further find that longer wavelength excitation is inefficient as the reduction in scattering is overcome by the decreased β far from resonance and the optimal excitation is within the 800-900 nm range. The impact is larger for backward collected SHG.
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