Evidence map›Paper›PMID 24686447›Full record

ArticleScientific reports2014

Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice.

Ryoko Kibe, Shin Kurihara, Yumi Sakai, Hideyuki Suzuki, Takushi Ooga, Emiko Sawaki, Koji Muramatsu, Atsuo Nakamura, Ayano Yamashita, Yusuke Kitada and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 2 syntheses or guidelines pooled it, 278 citations in OpenAlex.

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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Ryoko Kibe1] Benno Laboratory, RIKEN Innovation center, Wako, Saitama 351-0198, Japan [2].
Shin Kurihara1] Division of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto 606-8585, Japan [2] Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan [3] [4].
Yumi SakaiDivision of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.
Hideyuki SuzukiDivision of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.
Takushi OogaHuman Metabolome Technologies Inc., Tsuruoka, Yamagata 997-0052, Japan.
Emiko SawakiDairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
Koji MuramatsuDairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
Atsuo NakamuraDairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
Ayano YamashitaDairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
Yusuke KitadaDairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
Masaki KakeyamaLaboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Yoshimi BennoBenno Laboratory, RIKEN Innovation center, Wako, Saitama 351-0198, Japan.
Mitsuharu MatsumotoDairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Hinode, Nishitama, Tokyo 190-0182, Japan.
Megmilk Snow Brand (Japan) · JPKyoto Institute of Technology · JPRIKEN Nishina Center · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prevention of quality of life (QOL) deterioration is associated with the inhibition of geriatric diseases and the regulation of brain function. However, no substance is known that prevents the aging of both body and brain. It is known that polyamine concentrations in somatic tissues (including the brain) decrease with increasing age, and polyamine-rich foods enhance longevity in yeast, worms, flies, and mice, and protect flies from age-induced memory impairment. A main source of exogenous polyamines is the intestinal lumen, where they are produced by intestinal bacteria. We found that arginine intake increased the concentration of putrescine in the colon and increased levels of spermidine and spermine in the blood. Mice orally administered with arginine in combination with the probiotic bifidobacteria LKM512 long-term showed suppressed inflammation, improved longevity, and protection from age-induced memory impairment. This study shows that intake of arginine and LKM512 may prevent aging-dependent declines in QOL via the upregulation of polyamines.

Indexed as

AgingMicrobiotaAdministration, OralAnimalsArginineFecesFemaleIntestinesLongevityMaleMetabolomeMetabolomicsMicePolyaminesProbioticsPutrescineArgininePolyaminesPutrescine

Identifiers

PMID24686447
PMCPMC4070089
OpenAlexW1974483460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.