ArticlePlant physiology2014
Secreted fungal effector lipase releases free fatty acids to inhibit innate immunity-related callose formation during wheat head infection.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 132 citations in OpenAlex.
- A conserved fungal Egh16-like effector suppresses host defense by disrupting ATP binding of wheat MPK3.Journal of integrative plant biology · 2026Article
- Ustilago maydis Phosphatidic Acid and Phosphatidylserine-Targeting Secreted Lipase Lip3 Is Involved in Pathogenesis.Molecular plant pathology · 2026Article
- Fumarylacetoacetate hydrolase targeted by a Fusarium graminearum effector positively regulates wheat FHB resistance.Nature communications · 2025Article
- Proteomic Analysis of theJournal of fungi (Basel, Switzerland) · 2025Article
- Lipase domain effector AGLIP1 in Rhizoctonia solani triggers necrotic killing in plants.Plant cell reports · 2024Article
- Update on the Basic Understanding ofPlants (Basel, Switzerland) · 2024Review
- Advances in UnderstandingGenes · 2024Review
- Lipid profiling reveals Leymus Chinensis root insensitivity to Ca limitation.BMC plant biology · 2023Article
- Host Recognition and Specific Infection ofJournal of fungi (Basel, Switzerland) · 2023Article
- VqMAPK3/VqMAPK6, VqWRKY33, andHorticulture research · 2023Article
- Genetic and Transcriptional Regulatory Mechanisms of Lipase Activity in the Plant Pathogenic Fungus Fusarium graminearum.Microbiology spectrum · 2023Article
- Comparative transcriptomics identifies the keyFrontiers in genetics · 2023Article
- Microbial diversity in soils suppressive toFrontiers in plant science · 2023Review
- The N-terminus of a Fusarium graminearum-secreted protein enhances broad-spectrum disease resistance in plants.Molecular plant pathology · 2022Article
- Microscopic and Transcriptomic Comparison of Powdery Mildew Resistance in the Progenies ofInternational journal of molecular sciences · 2022Article
- Identification of a Novel Lipase with AHSMG Pentapeptide in Hypocreales and Glomerellales Filamentous Fungi.International journal of molecular sciences · 2022Article
- Unveiling the Core Effector Proteins of Oil Palm PathogenJournal of fungi (Basel, Switzerland) · 2022Article
- Sandwich Enzyme-Linked Immunosorbent Assay for Quantification of Callose.Methods and protocols · 2022Article
- Pathogen effectors: What do they do at plasmodesmata?Molecular plant pathology · 2022Review
- Fatty acid secretion by the white-rot fungus, Trametes versicolor.Journal of industrial microbiology & biotechnology · 2022Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The deposition of the (1,3)-β-glucan cell wall polymer callose at sites of attempted penetration is a common plant defense response to intruding pathogens and part of the plant's innate immunity. Infection of the Fusarium graminearum disruption mutant Δfgl1, which lacks the effector lipase FGL1, is restricted to inoculated wheat (Triticum aestivum) spikelets, whereas the wild-type strain colonized the whole wheat spike. Our studies here were aimed at analyzing the role of FGL1 in establishing full F. graminearum virulence. Confocal laser-scanning microscopy revealed that the Δfgl1 mutant strongly induced the deposition of spot-like callose patches in vascular bundles of directly inoculated spikelets, while these callose deposits were not observed in infections by the wild type. Elevated concentrations of the polyunsaturated free fatty acids (FFAs) linoleic and α-linolenic acid, which we detected in F. graminearum wild type-infected wheat spike tissue compared with Δfgl1-infected tissue, provided clear evidence for a suggested function of FGL1 in suppressing callose biosynthesis. These FFAs not only inhibited plant callose biosynthesis in vitro and in planta but also partially restored virulence to the Δfgl1 mutant when applied during infection of wheat spikelets. Additional FFA analysis confirmed that the purified effector lipase FGL1 was sufficient to release linoleic and α-linolenic acids from wheat spike tissue. We concluded that these two FFAs have a major function in the suppression of the innate immunity-related callose biosynthesis and, hence, the progress of F. graminearum wheat infection.
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