Evidence map›Paper›PMID 24686089›Full record

ReviewJournal of proteomics2014

MALDI imaging mass spectrometry: spatial molecular analysis to enable a new age of discovery.

Megan M Gessel, Jeremy L Norris, Richard M Caprioli

Abstract readHistorical ArticleReview
In one paragraph

Review in Journal of proteomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. MALDI spatial proteomics: a mini review of approaches and techniques.Analytical methods : advancing methods and applications · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Designing smart spatial omics experiments with S2Omics.bioRxiv : the preprint server for biology · 2025
    Article
  13. Review
  14. Cell-Instructive Biomaterials with Native-Like Biochemical Complexity.Annual review of biomedical engineering · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. MALDI TIMS IMS Reveals Ganglioside Molecular Diversity within MurineJournal of the American Society for Mass Spectrometry · 2024
    Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Megan M GesselNational Research Resource for Imaging Mass Spectrometry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, 9160 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8575, United States; Department of Biochemistry, Vanderbilt University School of Medicine, 9160 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8575, United States.
Jeremy L NorrisNational Research Resource for Imaging Mass Spectrometry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, 9160 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8575, United States; Department of Biochemistry, Vanderbilt University School of Medicine, 9160 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8575, United States.
Richard M CaprioliNational Research Resource for Imaging Mass Spectrometry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, 9160 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8575, United States; Department of Biochemistry, Vanderbilt University School of Medicine, 9160 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8575, United States. Electronic address: r.caprioli@vanderbilt.edu.

Funding

Training (pp 214-245)P41GM103391 · NIGMS · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M · 2012 to 2020
$17.7M
Spatial Analysis of Molecules in Tissue using MALDI-MSR01GM058008 · NIGMS · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M · 1998 to 2015
$5.8M
IMAGING MASS SPECTROMETRY RESEARCH RESOURCE AT VANDERBILT UNIVERSITYP41RR031461 · NCRR · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M · 2011 to 2011
$2.2M
Probing the Molecular Basis of Glomerular Injury in Diabetic NephropathyF32DK097875 · NIDDK · VANDERBILT UNIVERSITY · PI GESSEL, MEGAN MURRAY · 2013 to 2013
$39k
NCRR NIH HHS 5 P41 RR031461NCRR NIH HHS P41 RR031461NIDDK NIH HHS 1F32DK097875-01A1NIDDK NIH HHS F32 DK097875NIGMS NIH HHS 8 P41GM103391NIGMS NIH HHS P41 GM103391NIGMS NIH HHS R01 GM058008
6 · The paper itself

Abstract

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) combines the sensitivity and selectivity of mass spectrometry with spatial analysis to provide a new dimension for histological analyses to provide unbiased visualization of the arrangement of biomolecules in tissue. As such, MALDI IMS has the capability to become a powerful new molecular technology for the biological and clinical sciences. In this review, we briefly describe several applications of MALDI IMS covering a range of molecular weights, from drugs to proteins. Current limitations and challenges are discussed along with recent developments to address these issues. This article is part of a Special Issue entitled: 20years of Proteomics in memory of Viatliano Pallini. Guest Editors: Luca Bini, Juan J. Calvete, Natacha Turck, Denis Hochstrasser and Jean-Charles Sanchez.

Indexed as

Drug DiscoveryHistory, 20th CenturyHistory, 21st CenturyHumansProteinsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationProteinsMALDI imaging mass spectrometry

Identifiers

PMID24686089
PMCPMC4104210

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.