ArticleInfection and immunity2014
Novel pneumocystis antigen discovery using fungal surface proteomics.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
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- Characterization of theAntimicrobial agents and chemotherapy · 2024Article
- Genetic Mouse Models of Pneumocystis Pneumonia.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Germline IgM predicts T cell immunity to Pneumocystis.JCI insight · 2022Article
- Toward a humanized mouse model of Pneumocystis pneumonia.JCI insight · 2021Article
- Diagnosing Pneumocystis jirovecii pneumonia: A review of current methods and novel approaches.Medical mycology · 2020Review
- Transcriptomic and Proteomic Approaches to Finding Novel Diagnostic and Immunogenic Candidates inmSphere · 2019Article
- Is the unique camouflage strategy of Pneumocystis associated with its particular niche within host lungs?PLoS pathogens · 2019Review
- Pneumocystis and interactions with host immune receptors.PLoS pathogens · 2018Article
- Overcoming Hurdles to Development of a Vaccine against Pneumocystis jirovecii.Infection and immunity · 2017Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Pneumonia due to the fungus Pneumocystis jirovecii is a life-threatening infection that occurs in immunocompromised patients. The inability to culture the organism as well as the lack of an annotated genome has hindered antigen discovery that could be useful in developing novel vaccine- or antibody-based therapies as well as diagnostics for this infection. Here we report a novel method of surface proteomics analysis of Pneumocystis murina that reliably detected putative surface proteins that are conserved in Pneumocystis jirovecii. This technique identified novel CD4(+) T-cell epitopes as well as a novel B-cell epitope, Meu10, which encodes a glycosylphosphatidylinositol (GPI)-anchored protein thought to be involved in ascospore assembly. The described technique should facilitate the discovery of novel target proteins for diagnostics and therapeutics for Pneumocystis infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.