ArticleInfection and immunity2014
Identification of early interactions between Francisella and the host.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed.
- Modulatory Role of ATG5 Protein in Immune Modulation During Experimental Tularemia.Microorganisms · 2026Article
- Immunological changes associated with the treatment of pneumonic tularaemia in marmosets.Frontiers in cellular and infection microbiology · 2026Article
- Breathing and burning: metabolic control of alveolar macrophages by intracellular bacterial pathogens.Frontiers in physiology · 2026Review
- Non-hematopoietic tryptophan metabolism is a driver of ineffective T cell responses during secondary pulmonary bacterial infection.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- The immune response toFrontiers in microbiology · 2025Review
- Article
- Route of Francisella tularensis infection informs spatiotemporal metabolic reprogramming and inflammation in mice.PloS one · 2023Article
- Modeling Chronic Coccidioidomycosis in Mice.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Francisella tularensis Exploits AMPK Activation to Harvest Host-Derived Nutrients Liberated from Host Lipolysis.Infection and immunity · 2022Article
- Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity.iScience · 2021Article
- Aim2 and Nlrp3 Are Dispensable for Vaccine-Induced Immunity against Francisella tularensis Live Vaccine Strain.Infection and immunity · 2021Article
- Differential Immune Response Following Intranasal and Intradermal Infection withMicroorganisms · 2021Review
- Nlrp3 Increases the Host's Susceptibility to Tularemia.Frontiers in microbiology · 2021Article
- Tn-Seq reveals hidden complexity in the utilization of host-derived glutathione in Francisella tularensis.PLoS pathogens · 2020Article
- Contributions of TolC Orthologs toInfection and immunity · 2019Article
- Polymer-augmented liposomes enhancing antibiotic delivery against intracellular infections.Biomaterials science · 2018Article
- Detrimental Influence of Alveolar Macrophages on Protective Humoral Immunity during Francisella tularensis SchuS4 Pulmonary Infection.Infection and immunity · 2018Article
- Complement C3 as a Prompt for Human Macrophage Death during Infection with Francisella tularensis Strain SCHU S4.Infection and immunity · 2017Article
- Protective Role for Macrophages in Respiratory Francisella tularensis Infection.Infection and immunity · 2017Article
- Innate Immune Recognition: Implications for the Interaction ofFrontiers in cellular and infection microbiology · 2017Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The adaptive immune response to Francisella tularensis is dependent on the route of inoculation. Intradermal inoculation with the F. tularensis live vaccine strain (LVS) results in a robust Th1 response in the lungs, whereas intranasal inoculation produces fewer Th1 cells and instead many Th17 cells. Interestingly, bacterial loads in the lungs are similar early after inoculation by these two routes. We hypothesize that the adaptive immune response is influenced by local events in the lungs, such as the type of cells that are first infected with Francisella. Using fluorescence-activated cell sorting, we identified alveolar macrophages as the first cell type infected in the lungs of mice intranasally inoculated with F. novicida U112, LVS, or F. tularensis Schu S4. Following bacterial dissemination from the skin to the lung, interstitial macrophages or neutrophils are infected. Overall, we identified the early interactions between Francisella and the host following two different routes of inoculation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.