ArticleJournal of hypertension2014
Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping.
Article in Journal of hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 66 citations in OpenAlex.
- The role of cellular senescence in cardiovascular disease.Cell death discovery · 2025Review
- The relationship between telomere length and aging-related diseases.Clinical and experimental medicine · 2025Review
- Single-cell RNA sequencing analysis reveals the critical role of fibroblasts in aortic progeria-associated vascular remodeling in Hutchinson-Gilford progeria syndrome mice.Frontiers in immunology · 2025Article
- Article
- Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases: Therapeutic Implications:JACC. Basic to translational science · 2024Review
- The long and the short of it: Salivary telomere length as a candidate biomarker for hypertension and age-related changes in blood pressure.Physiological reports · 2024Article
- Hypertension and cellular senescence.Biogerontology · 2023Review
- Mediating effect of telomere length in a hypertension population exposed to cadmium: a case-control study.Journal of human hypertension · 2023Article
- Heterogenous Differences in Cellular Senescent Phenotypes in Pre-Eclampsia and IUGR following Quantitative Assessment of Multiple Biomarkers of Senescence.International journal of molecular sciences · 2023Article
- The Telomere-Telomerase System Is Detrimental to Health at High-Altitude.International journal of environmental research and public health · 2023Article
- Mechanisms and consequences of endothelial cell senescence.Nature reviews. Cardiology · 2023Review
- Telomere Length: A Cardiovascular Biomarker and a Novel Therapeutic Target.International journal of molecular sciences · 2022Review
- Article
- The Length of Leukocyte and Femoral Artery Telomeres in Patients with Peripheral Atherosclerosis.Genes · 2022Article
- Telomere length and the risk of cardiovascular diseases: A Mendelian randomization study.Frontiers in cardiovascular medicine · 2022Article
- A potential role of autophagy-mediated vascular senescence in the pathophysiology of HFpEF.Frontiers in endocrinology · 2022Review
- Vascular Stress Signaling in Hypertension.Circulation research · 2021Review
- Telomere Shortening and Accelerated Aging in US Military Veterans.International journal of environmental research and public health · 2021Article
- Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology.Cellular and molecular life sciences : CMLS · 2021Review
- High-fat diet induced obesity and age influence the telomere shelterin complex and telomerase gene expression in mouse adipose tissue.Physiological reports · 2020Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTelomere shortening in arteries could lead to telomere uncapping and cellular senescence, which in turn could promote the development of hypertension. METHODS AND
resultsTo assess the novel role of arterial telomere dysfunction in hypertension, we compared mean telomere length (qPCR), telomere uncapping (serine 139 phosphorylated histone γ-H2A.X (γ-H2) localized to telomeres: ChIP), and tumor suppressor protein p53 (P53)/cyclin-dependent kinase inhibitor 1A (P21)-induced senescence (P53 bound to P21 gene promoter: ChIP) in arteries from 55 age-matched hypertensive and nonhypertensive individuals. Arterial mean telomere length was not different in hypertensive patients compared with nonhypertensive individuals (P = 0.29). Arterial telomere uncapping and P53/P21-induced senescence were two-fold greater in hypertensive patients compared with nonhypertensive individuals (P = 0.04 and P = 0.02, respectively). Arterial mean telomere length was not associated with telomere uncapping or P53/P21-induced senescence (r = -0.02, P = 0.44 and r = 0.01, P = 0.50, respectively), but telomere uncapping was a highly influential covariate for the hypertension group difference in P53/P21-induced senescence (r = 0.62, P < 0.001, η(p)(2) = 0.35). Finally, telomere uncapping was a significant predictor of hypertension status (P = 0.03), whereas mean telomere length was not (P = 0.68).
conclusionCollectively, these findings demonstrate that arterial telomere uncapping and P53/P21-induced senescence are linked to hypertension independently of mean telomere length, and telomere uncapping influences hypertension status more than mean telomere length.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.