ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2014
Priapism in homozygous sickle cell patients: important clinical and laboratory associations.
Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- A systematic literature review of frequency of vaso-occlusive crises in sickle cell disease.Orphanet journal of rare diseases · 2021Pooled it
- Priapism in sickle cell disease: Associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers.PloS one · 2021Article
- Effects of Environmental and Pathological Hypoxia on Male Fertility.Frontiers in cell and developmental biology · 2021Review
- Management of Sickle Cell Disease Complications Beyond Acute Chest Syndrome.Journal of blood medicine · 2021Review
- Clinical and laboratory parameters, risk factors predisposing to the development of priapism in sickle cell patients.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Priapism, hemoglobin desaturation, and red blood cell adhesion in men with sickle cell anemia.Blood cells, molecules & diseases · 2019Article
- Hypoxia-enhanced adhesion of red blood cells in microscale flow.Microcirculation (New York, N.Y. : 1994) · 2017Article
- Current Standards of Care and Long Term Outcomes for Thalassemia and Sickle Cell Disease.Advances in experimental medicine and biology · 2017Review
- Article
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the relationship between the occurrence of priapism and important steady-state clinical and laboratory parameters in homozygous sickle cell disease (SCD). SUBJECTS AND
methodsSteady-state clinical and laboratory data were obtained from the medical records of 126 male patients seen in the clinic over a 7-year period. Estimated prevalence rates, correlation coefficients and independent t tests were calculated to assess the relationship between priapism and several important clinical and laboratory indices. Patient data on age, haemoglobin concentrations, the frequency of crises per annum, leucocyte counts, platelet counts, serum bilirubin and aspartate transaminase were evaluated.
resultsThe prevalence of priapism was determined to be 21.4%, and 22.2% of those affected had erectile dysfunction. There was a significant positive correlation between priapism and older age (p = 0.049) and lower leucocyte counts (p = 0.008). There was no significant relationship with other clinical or laboratory indices.
conclusionAbout 1 in 4 of all homozygous older SCD patients had priapism, and an approximately similar ratio developed erectile dysfunction; they also had lower steady-state leucocyte counts. Other clinical and laboratory indicators of disease severity in SCD did not positively correlate with the occurrence of priapism, and this may imply an alternative pathogenetic mechanism.
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