ArticleJournal of Alzheimer's disease : JAD2014
Increased hippocampal blood flow in sedentary older adults at genetic risk for Alzheimer's disease.
Article in Journal of Alzheimer's disease : JAD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Sedentary behavior, cognition, and brain health in older adults: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- Apolipoprotein E Genotype Moderation of the Association Between Physical Activity and Brain Health. A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Brain Perfusion Change in Patients with Mild Cognitive Impairment After 12 Months of Aerobic Exercise Training.Journal of Alzheimer's disease : JAD · 2020Trial
- Review
- Elevated cerebral blood flow proxy with increased beta-amyloid burden in Alzheimer's disease preclinical phase evaluated by dual-phaseScientific reports · 2024Article
- Education reduces cognitive dysfunction in Alzheimer's disease by changing regional cerebral perfusion: An in-vivo arterial spin labeling study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer's disease risk? A novel integrative model.Alzheimer's research & therapy · 2023Review
- Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer's disease.Frontiers in neuroscience · 2023Article
- Mediation of the APOE Associations With Cognition Through Cerebral Blood Flow: The CIBL Study.Frontiers in aging neuroscience · 2022Article
- Aerobic exercise, cardiorespiratory fitness, and the human hippocampus.Hippocampus · 2021Review
- ApoE and cerebral insulin: Trafficking, receptors, and resistance.Neurobiology of disease · 2020Review
- Regulating effect of CBF on memory in cognitively normal older adults with different ApoE genotype: the Alzheimer's Disease Neuroimaging Initiative (ADNI).Cognitive neurodynamics · 2019Article
- Dose-dependent association of accelerometer-measured physical activity and sedentary time with brain perfusion in aging.Experimental gerontology · 2019Article
- Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Racial/ethnic variation ofNeurology · 2018Article
- Article
- The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects.Frontiers in aging neuroscience · 2018Article
- Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults.PloS one · 2018Article
- Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults.Frontiers in aging neuroscience · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Resting cerebral blood flow (CBF) decreases with age; however regulatory increases in hippocampal CBF have been associated with genetic risk (Apolipoprotein E [APOE] ε4 carriers) for Alzheimer's disease (AD). Although physical activity exerts beneficial effects on CBF in healthy elderly, the effects of sedentary behaviors on CBF remain unknown. We measured resting hippocampal CBF (via arterial spin labeling magnetic resonance imaging) and sedentary time/physical activity (via accelerometry) on 33 cognitively healthy adults (ages 52-81), 9 of which were APOE ε4 carriers. Results indicate that the relationship between sedentary time and CBF in the left hippocampus differs by APOE status, whereby APOE ε4 carriers show higher CBF as a function of longer sedentary time (B = 10.8, SE = 3.17, β = 0.74, t = 3.41, p < 0.01) compared to noncarriers (B = 1.4, SE = 2.7, β = 0.096, t = 0.51, p = 0.61), possibly suggesting a CBF regulatory response to compensate for metabolic alterations in dementia risk. These preliminary data suggest that the relationship between CBF and sedentary time is different in APOE ε4 carriers and noncarriers and that sedentary time may act as a behavioral risk factor for CBF dysregulation in those at genetic risk for developing AD. More research is needed to further understand the role of sedentary behaviors and physical activity on CBF, especially in individuals at genetic risk of developing AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.