ArticleJournal of Alzheimer's disease : JAD2014
Neuroanatomical correlates of emotional blunting in behavioral variant frontotemporal dementia and early-onset Alzheimer's disease.
Article in Journal of Alzheimer's disease : JAD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebral Volumetric Correlates of Apathy in Alzheimer's Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort.Journal of Alzheimer's disease : JAD · 2022Pooled it
- Excessive emotional reactivity in a case of behavioral variant frontotemporal dementia with amyotrophic lateral sclerosis.Psychiatry research case reports · 2025Article
- Investigating Neuroimaging Correlates of Early Frailty in Patients With Behavioral Variant Frontotemporal Dementia: A MRI and FDG-PET Study.Frontiers in aging neuroscience · 2021Article
- A Critical Review of Behavioral and Emotional Disinhibition.The Journal of nervous and mental disease · 2020Review
- Impact of Aging on Empathy: Review of Psychological and Neural Mechanisms.Frontiers in psychiatry · 2019Review
- Motor signatures of emotional reactivity in frontotemporal dementia.Scientific reports · 2018Article
- Screening for Emotional Expression in Frontotemporal Dementia: A Pilot Study.Behavioural neurology · 2018Article
- Skin Conduction Levels Differentiate Frontotemporal Dementia From Alzheimer's Disease.The Journal of neuropsychiatry and clinical neurosciences · 2018Article
- Lower Visual Avoidance in Dementia Patients Is Associated with Greater Psychological Distress in Caregivers.Dementia and geriatric cognitive disorders · 2017Article
- Structural and functional brain abnormalities place phenocopy frontotemporal dementia (FTD) in the FTD spectrum.NeuroImage. Clinical · 2016Article
- Article
- White Matter Changes Associated with Resting Sympathetic Tone in Frontotemporal Dementia vs. Alzheimer's Disease.PloS one · 2015Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundEmotional blunting is a characteristic feature of behavioral variant frontotemporal dementia (bvFTD) and can help discriminate between patients with bvFTD and other forms of younger-onset dementia.
objectiveWe compared the presence of emotional blunting symptoms in patients with bvFTD and early-onset Alzheimer's disease (AD), and investigated the neuroanatomical associations between emotional blunting and regional brain volume.
methodsTwenty-five individuals with bvFTD (n = 11) and early-onset AD (n = 14) underwent magnetic resonance imaging (MRI) and were rated on symptoms of emotional blunting using the Scale for Emotional Blunting (SEB). The two groups were compared on SEB ratings and MRI-derived brain volume using tensor-based morphometry. Voxel-wise linear regression was performed to determine neuroanatomical correlates of SEB scores.
resultsThe bvFTD group had significantly higher SEB scores compared to the AD group. On MRI, bvFTD patients had smaller bilateral frontal lobe volume compared to AD patients, while AD patients had smaller bilateral temporal and left parietal volume than bvFTD patients. In bvFTD, SEB ratings were strongly correlated with right anterior temporal volume, while the association between SEB and the right orbitofrontal cortex was non-significant.
conclusionsSymptoms of emotional blunting were more prevalent in bvFTD than early-onset AD patients. These symptoms were particularly associated with right-sided atrophy, with significant involvement of the right anterior temporal region. Based on these findings, the SEB appears to measure symptoms of emotional blunting that are localized to the right anterior temporal lobe.
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