ArticleCell reports2014
The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- The homeobox transcription factor MNX1 regulates the expression of many non-MN-specific neuronal genes in motor neurons.Nucleic acids research · 2025Article
- Evolutionary conservation of midline repulsive signaling by Robo family receptors in flies and mice.Developmental biology · 2025Article
- The Slit-Robo signalling pathway in nervous system development: a comparative perspective from vertebrates and invertebrates.Open biology · 2025Review
- Article
- Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation.BMC molecular and cell biology · 2021Article
- LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.Molecular biology of the cell · 2020Article
- Effect of sonic hedgehog on motor neuron positioning in the spinal cord during chicken embryonic development.Journal of cellular and molecular medicine · 2019Article
- A gene expression atlas of embryonic neurogenesis inDevelopment (Cambridge, England) · 2019Article
- Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Islet Coordinately Regulates Motor Axon Guidance and Dendrite Targeting through the Frazzled/DCC Receptor.Cell reports · 2017Article
- Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes.Cell reports · 2016Article
- Article
- Specification of Dendritogenesis Site in Drosophila aCC Motoneuron by Membrane Enrichment of Pak1 through Dscam1.Developmental cell · 2015Article
- Slit Binding via the Ig1 Domain Is Essential for Midline Repulsion by Drosophila Robo1 but Dispensable for Receptor Expression, Localization, and Regulation in Vivo.G3 (Bethesda, Md.) · 2015Article
- Article
- Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube.Experimental neurology · 2015Article
- Zebrafish foxc1a drives appendage-specific neural circuit development.Development (Cambridge, England) · 2015Article
- Transcription factors and effectors that regulate neuronal morphology.Development (Cambridge, England) · 2014Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Transcription factors establish neural diversity and wiring specificity; however, how they orchestrate changes in cell morphology remains poorly understood. The Drosophila Roundabout (Robo) receptors regulate connectivity in the CNS, but how their precise expression domains are established is unknown. Here, we show that the homeodomain transcription factor Hb9 acts upstream of Robo2 and Robo3 to regulate axon guidance in the Drosophila embryo. In ventrally projecting motor neurons, hb9 is required for robo2 expression, and restoring Robo2 activity in hb9 mutants rescues motor axon defects. Hb9 requires its conserved repressor domain and functions in parallel with Nkx6 to regulate robo2. Moreover, hb9 can regulate the medio-lateral position of axons through robo2 and robo3, and restoring robo3 expression in hb9 mutants rescues the lateral position defects of a subset of neurons. Altogether, these data identify Robo2 and Robo3 as key effectors of Hb9 in regulating nervous system development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.