ArticleJournal of the American Society of Hypertension : JASH2014
Detection of early diastolic alterations by tissue Doppler imaging in untreated childhood-onset essential hypertension.
Article in Journal of the American Society of Hypertension : JASH, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Cardiovascular implications in adolescent and young adult hypertension.Reviews in cardiovascular medicine · 2022Pooled it
- Prevalence of left ventricular hypertrophy in children and young people with primary hypertension: Meta-analysis and meta-regression.Frontiers in cardiovascular medicine · 2022Pooled it
- Pediatric Ambulatory Blood Pressure Patterns and Cardiovascular Risk.Current hypertension reports · 2026Review
- Hypertension: An Important But Reversible Cause of Systolic Dysfunction in a Cohort of Pediatric Patients.Pediatric cardiology · 2024Article
- Ultrasonography to detect cardiovascular damage in children with essential hypertension.Cardiovascular ultrasound · 2021Article
- Subclinical Systolic and Diastolic Dysfunction Is Evident in Youth With Elevated Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Comparison of echocardiographic changes in children with primary hypertension and hypertension due to mild to moderate chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Article
- Epidemiology of Childhood Onset Essential Hypertension.Journal of human hypertension · 2018Observational
- Early myocardial changes in normotensive children of hypertensive parents: a tissue Doppler study.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Blood pressure is normal, but is the heart?Pediatric nephrology (Berlin, Germany) · 2018Observational
- Cardiac and Vascular Target Organ Damage in Pediatric Hypertension.Frontiers in pediatrics · 2018Article
- Commentary: Left Ventricular Hypertrophy in Pediatric Hypertension: A Mini Review.Frontiers in pediatrics · 2017Article
- Left Ventricular Hypertrophy Phenotype in Childhood-Onset Essential Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Myocardial Performance Index in Childhood Onset Essential Hypertension and White Coat Hypertension.American journal of hypertension · 2016Article
- Left ventricular hypertrophy and diastolic function in children and adolescents with essential hypertension.Clinical hypertension · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
The aim of the study was to determine the presence of preclinical diastolic dysfunction in hypertensive children relative to normotensive children by Tissue Doppler Imaging (TDI). We prospectively enrolled children with untreated essential hypertension in absence of any other disease and a matched healthy control group with normal blood pressure (BP); both groups confirmed by clinic BP and a 24-hour ambulatory BP monitoring. Echocardiographic diastolic parameters were determined using spectral transmitral inflow Doppler, flow propagation velocity, TDI, and systolic parameters were determined via midwall shortening fraction and ejection fraction. A total of 80 multiethnic children were prospectively enrolled for the study: 46 hypertensive (median age, 13 years; 72% males) and 34 control (median age, 14 years; 65% males). The only echocardiography parameters that had a statistically significant change compared with the control children, were regional mitral Ea, Aa, and the E/Ea ratio by TDI. In comparison with controls, hypertensive children had lower Ea and Aa velocities of anterior and posterior walls and higher lateral wall E/Ea ratio. The decrease in posterior wall Ea and Aa remained significant after adjustment for gender, age, body mass index, ethnicity, and left ventricular hypertrophy on multivariate analysis. The lateral and septal wall E/Ea ratios correlated significantly with fasting serum insulin levels on similar multivariate analysis. Decreased regional TDI velocities were seen with preserved left ventricular systolic function even when other measures of diastolic dysfunction remained unchanged in untreated hypertensive children. Hypertension and serum insulin levels had strong associations with preclinical diastolic alterations in children.
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