ReviewMayo Clinic proceedings2014
Immunomodulatory effects of sex hormones: requirements for pregnancy and relevance in melanoma.
Review in Mayo Clinic proceedings, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 62 citations in OpenAlex.
- Sex-related differences in markers of immune activation in virologically suppressed HIV-infected patients.Biology of sex differences · 2020Trial
- Innate Immunity and Microbial Recognition in Reproduction: From Barrier Defense to Maternal-Fetal Tolerance.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Gestational breast cancer: distinctive molecular and clinico-epidemiological features.Journal of mammary gland biology and neoplasia · 2024Observational
- Exploratory profiles of phenols, parabens, and per- and poly-fluoroalkyl substances among NHANES study participants in association with previous cancer diagnoses.Journal of exposure science & environmental epidemiology · 2023Article
- Prediction of human protein interactome of dengue virus non-structural protein 5 (NS5) and its downstream immunological implications.3 Biotech · 2023Article
- Possible Association Between Melanoma Arising from Congenital Naevus and Oestrogen or Progesterone Receptor Expression: Clinicopathological Analysis.Acta dermato-venereologica · 2023Article
- Exogenous Hormone Factors in Relation to the Risk of Malignant Melanoma in Women: A Systematic Review and Meta-Analysis.Cancers · 2022Review
- Changing epidemiology and age-specific incidence of cutaneous malignant melanoma in Lithuania: an analysis of national cancer registration data by gender and anatomical site, 1991-2015.Contemporary oncology (Poznan, Poland) · 2022Article
- Genetic Relationship Between Endometriosis and Melanoma.Frontiers in reproductive health · 2021Article
- Changes in physiology and immune system during pregnancy and coronavirus infection: A review.European journal of obstetrics, gynecology, and reproductive biology · 2020Review
- Multiomic immune clockworks of pregnancy.Seminars in immunopathology · 2020Review
- Melanoma in pregnancy: certainties unborn.Melanoma management · 2020Review
- Maternal T Cells in the Human Placental Villi Support an Allograft Response during Noninfectious Villitis.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Upregulation of HLA-Class I and II in Placentas Diagnosed with Villitis of Unknown Etiology.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Medawar's Paradox and Immune Mechanisms of Fetomaternal Tolerance.OBM transplantation · 2020Article
- Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases.Frontiers in immunology · 2020Review
- Zika virus infection differentially affects genome-wide transcription in neuronal cells and myeloid dendritic cells.PloS one · 2020Article
- Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer.BMC cancer · 2019Article
- Total Body Photography and Sequential Digital Dermoscopy in Pregnant Women.Dermatology practical & conceptual · 2019Article
- Pulmonary group 2 innate lymphoid cells: surprises and challenges.Mucosal immunology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Similarities between the pathologic progression of cancer and the physiologic process of placentation (eg, proliferation, invasion, and local/systemic tolerance) have been recognized for many years. Sex hormones such as human chorionic gonadotropin, estrogens, progesterone, and others contribute to induction of immunologic tolerance at the beginning of gestation. Sex hormones have been shown to play contributory roles in the growth of cancers such as breast cancer, prostrate cancer, endometrial cancer, and ovarian cancer, but their involvement as putative mediators of the immunologic escape of cancer is still being elucidated. Herein, we compare the emerging mechanism by which sex hormones modulate systemic immunity in pregnancy and their potentially similar role in cancer. To do this, we conducted a PubMed search using combinations of the following keywords: "immune regulation," "sex hormones," "pregnancy," "melanoma," and "cancer." We did not limit our search to specific publication dates. Mimicking the maternal immune response to pregnancy, especially in late gestation, might aid in design of better therapies to reconstitute endogenous antitumor immunity and improve survival.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.