ArticleNeurobiology of aging2014
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
Article in Neurobiology of aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Trans-Ethnic Meta-Analysis of Interactions Between Genetics and Early-Life Socioeconomic Context on Memory Performance and Decline in Older Americans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Pooled it
- Effects of early- and mid-life stress on DNA methylation of genes associated with subclinical cardiovascular disease and cognitive impairment: a systematic review.BMC medical genetics · 2019Pooled it
- Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes.Schizophrenia bulletin · 2015Pooled it
- Trial
- Different responses to risperidone treatment in Schizophrenia: a multicenter genome-wide association and whole exome sequencing joint study.Translational psychiatry · 2022Article
- Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning.Genes, brain, and behavior · 2021Article
- Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population.Social science & medicine (1982) · 2021Article
- Neuroimaging endophenotypes of type 2 diabetes mellitus: a discordant sibling pair study.Quantitative imaging in medicine and surgery · 2019Article
- Phenotypic heterogeneity in m.3243A>G mitochondrial disease: The role of nuclear factors.Annals of clinical and translational neurology · 2018Article
- Article
- Analysis of the relationships between type 2 diabetes status, glycemic control, and neuroimaging measures in the Diabetes Heart Study Mind.Acta diabetologica · 2016Article
- Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study.Brain and behavior · 2016Article
- Plasma Clusterin and the CLU Gene rs11136000 Variant Are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients.Frontiers in aging neuroscience · 2016Article
- Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study.Neurobiology of aging · 2015Article
- Heritability of cognitive traits among siblings with a parental history of Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2015Article
- Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes.Journal of diabetes and its complicationsArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Cognitive performance is an important component of healthy aging. Type 2 diabetes (T2D) is associated with negative outcomes for the brain and cognition, although causal mechanisms have not been definitely determined. Genetic risk factors warrant further consideration in this context. This study examined the heritability of cognitive function as assessed by (1) the Digit Symbol Substitution Task; (2) the Modified Mini-Mental State Examination; (3) the Stroop Task; (4) the Rey Auditory-Verbal Learning Task; and (5) the Controlled Oral Word Association Task for Phonemic and Semantic Fluency, in the family-based, T2D-enriched, Diabetes Heart Study sample (n = 550 participants from 257 families). The genetic basis of these cognitive measures was further evaluated by association analysis with candidate single-nucleotide polymorphisms (SNPs) and genome-wide SNP data. Measures of cognitive function were significantly heritable (hˆ(2) = 0.28-0.62) following adjustment for age, gender, and education. A total of 31 SNPs (from 26 genes/regions) selected to form an a priori set of candidate SNPs showed limited evidence of association with cognitive function when applying conservative metrics of significance. Genome-wide assessment of both noncoding and coding variants revealed suggestive evidence of association for several coding variants including rs139509083 in CNST (p = 4.9 × 10(-9)), rs199968569 in PLAA (p = 4.9 × 10(-9)) and rs138487371 in PCDH8 (p = 3.7 × 10(-8)). The identification of a heritable component to cognitive performance in T2D suggests a role for genetic contributors to cognitive performance even in the presence of metabolic disease and other associated comorbidities and is supported by the identification of genetic association signals in functionally plausible candidates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.