ArticleJournal of veterinary internal medicine
The effect of tramadol and indomethacin coadministration on gastric barrier function in dogs.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Analgesia for Sheep in Commercial Production: Where to Next?Animals : an open access journal from MDPI · 2021Review
- Safety and efficacy of reduced dosage ketoprofen with or without tramadol for long-term treatment of osteoarthritis in dogs: a randomized clinical trial.BMC veterinary research · 2019Article
- Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs.Journal of veterinary internal medicine · 2018Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundTramadol is a centrally acting analgesic that is often used in conjunction with nonsteroidal anti-inflammatory drugs (NSAIDs). The effect of coadministration of tramadol and indomethacin on gastric barrier function in dogs is unknown. HYPOTHESIS/
objectivesThat coadministration of a nonselective NSAID (indomethacin) and tramadol would decrease recovery of barrier function as compared with acid-injured, indomethacin-treated, and tramadol-treated mucosa. ANIMALS: Gastric mucosa of 10 humanely euthanized shelter dogs.
methodsEx vivo study. Mounted gastric mucosa was treated with indomethacin, tramadol, or both. Gastric barrier function, prostanoid production, and cyclooxygenase expression were quantified.
resultsIndomethacin decreased recovery of transepithelial electrical resistance after injury, although neither tramadol nor the coadministration of the two had an additional effect. Indomethacin inhibited production of gastroprotective prostanoids prostaglandin E2 (acid-injured PGE2 : 509.3 ± 158.3 pg/mL, indomethacin + acid injury PGE2 : 182.9 ± 93.8 pg/mL, P < .001) and thromboxane B2 (acid-injured TXB2 : 233.2 ± 90.7 pg/mL, indomethacin + acid injury TXB2 : 37.9 ± 16.8 pg/mL, P < .001), whereas tramadol had no significant effect (PGE2 P = .713, TXB2 P = .194). Neither drug had an effect on cyclooxygenase expression (COX-1 P = .743, COX-2 P = .705). Acid injury induced moderate to marked epithelial cell sloughing, which was unchanged by drug administration. CONCLUSIONS AND CLINICAL IMPORTANCE: There was no apparent interaction of tramadol and a nonselective cyclooxygenase in this ex vivo model. These results suggest that if there is an adverse interaction of the 2 drugs in vivo, it is unlikely to be via prostanoid inhibition.
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