Evidence map›Paper›PMID 24684466›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2014

Teriparatide increases strength of the peripheral skeleton in premenopausal women with idiopathic osteoporosis: a pilot HR-pQCT study.

Kyle K Nishiyama, Adi Cohen, Polly Young, Ji Wang, Joan M Lappe, X Edward Guo, David W Dempster, Robert R Recker, Elizabeth Shane

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Bone Density After Teriparatide Discontinuation in Premenopausal Idiopathic Osteoporosis.The Journal of clinical endocrinology and metabolism · 2015
    Trial
  5. Comparative effects of teriparatide, denosumab, and combination therapy on peripheral compartmental bone density, microarchitecture, and estimated strength: the DATA-HRpQCT Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015
    Trial
  6. Article
  7. The impact of segmentation approach on HR-pQCT microarchitectural and biomechanical metrics depends on bone structure.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. A Laplace-Hamming Binarization Approach for Second-Generation HR-pQCT Rescues Fine Feature Segmentation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  12. The Clinical and Skeletal Effects of Long-Term Therapy of Hypoparathyroidism With rhPTH(1-84).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  13. Review
  14. The clinical application of high-resolution peripheral computed tomography (HR-pQCT) in adults: state of the art and future directions.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Review
  15. Role of bone-forming agents in the management of osteoporosis.Aging clinical and experimental research · 2021
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kyle K NishiyamaDivision of Endocrinology (K.K.N., A.C., P.Y., E.S.), Department of Medicine, and Department of Pathology (D.W.D.), College of Physicians and Surgeons, Columbia University, New York, New York 10032; Department of Biomedical Engineering (J.W., X.E.G.), Columbia University, New York, New York 10027; and Division of Endocrinology (J.M.L., R.R.R.), Department of Medicine, Creighton University, Omaha, Nebraska 68131.
Adi Cohen
Polly Young
Ji Wang
Joan M Lappe
X Edward Guo
David W Dempster
Robert R Recker
Elizabeth Shane
Columbia University · USCreighton University · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Micro-Mechanical Modeling of Trabecular BoneR01AR051376 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GUO, X. EDWARD · 2006 to 2015
$3.2M
Clinical Bone Mechanics Using HR-pQCT and ??MRIR01AR058004 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GUO, X. EDWARD, SHANE, ELIZABETH J · 2010 to 2014
$3.1M
Idiopathic Osteoporosis in Premenopausal WomenK24AR052665 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHANE, ELIZABETH J · 2005 to 2014
$1.8M
Bone Quality in Premenopausal Women with Idiopathic Fragility FracturesK23AR054127 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COHEN, ADI · 2007 to 2011
$642k
NCRR NIH HHS UL1 RR024156NIAMS NIH HHS 1K23 AR054127NIAMS NIH HHS 2K24 AR052665NIAMS NIH HHS K23 AR054127NIAMS NIH HHS K24 AR052665NIAMS NIH HHS R01 AR051376NIAMS NIH HHS R01 AR058004NIAMS NIH HHS R01 AR49893
6 · The paper itself

Abstract

contextIn premenopausal women with idiopathic osteoporosis (IOP), treatment with teriparatide leads to substantial improvement in bone density and quality at central skeletal sites. The effects of teriparatide may differ on cortical and trabecular bone and also at the central and the peripheral skeleton.

objectiveThe objective of the study was to determine whether teriparatide was associated with improvements in compartmental volumetric bone mineral density (BMD), bone microarchitecture, and estimated bone strength of the distal radius and tibia as assessed by high-resolution peripheral quantitative computed tomography. DESIGN, SETTING, AND

participantsPremenopausal women (n = 20, age 41 ± 5 y) with IOP (low trauma fractures and/or Z-scores ≤ -2.0) were scanned with high-resolution peripheral quantitative computed tomography at baseline and after 18 months of teriparatide treatment. Cortical and trabecular volumetric BMD and microarchitecture were measured by both standard and advanced techniques, including individual trabecula segmentation, and bone strength was estimated by finite element analysis.

main outcome measuresThe total volumetric BMD and homogeneous bone stiffness were measured.

resultsTrabecular volumetric BMD increased significantly by 2.6% (1.8, 6.2) [median (interquartile range)] at the radius and 2.5% (1.1, 3.6) at the tibia. In addition, trabecular plate bone volume fraction increased by 9.1% (2.1, 17.1) at the radius and 7.6% (1.0, 9.7) at the tibia. Cortical thickness and volumetric density did not change; however, cortical porosity increased at the radius but not at the tibia. Despite these changes, whole-bone stiffness and failure load estimated by finite element analysis increased at both the radius and tibia.

conclusionsIn premenopausal women with IOP, 18 months of teriparatide was associated with increases in trabecular volumetric BMD, improved trabecular microarchitecture, and estimated bone strength at both the radius and tibia.

Indexed as

AdultBone and BonesBone DensityBone Density Conservation AgentsFemaleFractures, BoneHumansMechanical PhenomenaMiddle AgedOsteoporosisPilot ProjectsPremenopauseTeriparatideTomography, X-Ray ComputedBone Density Conservation AgentsTeriparatide

Identifiers

PMID24684466
PMCPMC4079304
OpenAlexW2072027816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.