ArticleThe Journal of clinical endocrinology and metabolism2014
The impact of obesity on the presentation of primary hyperparathyroidism.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Reference interval of parathyroid hormone based on the Korea National Health and Nutrition Examination Survey 2024.BMC endocrine disorders · 2026Article
- Renal calcifications and primary hyperpara-thyroidism in a tertiary care hospital center of North Africa: a single-center experience.Medicine and pharmacy reports · 2026Article
- Anthropometric Indices and Markers of Atherothrombotic Risk in Subjects with Primary Hyperparathyroidism.Metabolites · 2026Article
- Prevalence and Associations of Preoperative Micronutrient Deficiencies in Bariatric Surgery Candidates with Severe Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- The impact of body mass index on the diagnostic and surgical outcomes in primary hyperparathyroidism.Revista da Associacao Medica Brasileira (1992) · 2025Article
- The predictive value of 24-hour urinary calcium for kidney stone risk in primary hyperparathyroidism: insight from a retrospective study of parathyroid adenoma cases.Frontiers in endocrinology · 2025Article
- Sex-Stratified Predictors of Prolonged Operative Time and Hospital Admission in Outpatient Parathyroidectomy.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Recurrent Urolithiasis Revealing Primary Hyperparathyroidism in a Nephrology Department.Case reports in nephrology · 2024Article
- Parathyroid diseases and metabolic syndrome.Journal of endocrinological investigation · 2023Review
- Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Review
- The predictive role of parathyroid hormone for non-alcoholic fatty liver disease based on invasive and non-invasive findings in candidates of bariatric surgery.Eating and weight disorders : EWD · 2022Article
- The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery.Journal of nutrition and metabolism · 2022Article
- Patterns of Calcium- and Chloride-Ion Disorders and Predictors among Obese Outpatient Adults in Southern Ethiopia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism.International journal of molecular sciences · 2020Review
- Association of body mass index and waist circumference with osteocalcin and C-terminal telopeptide in Iranian elderly: results from a cross-sectional study.Journal of bone and mineral metabolism · 2019Article
- Occult urolithiasis in asymptomatic primary hyperparathyroidism.Endocrine research · 2018Article
- Parathyroid hormone stimulates adipose tissue browning: a pathway to muscle wasting.Current opinion in clinical nutrition and metabolic care · 2017Review
- Occurrence of Klinefelter Syndrome Mosaic 45,X/46,XY/47,XXY/48,XXYY/48,XXXY and Primary Hyperparathyroidism.AACE clinical case reportsArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
contextObesity has been associated with elevated serum PTH (sPTH) in the general population. Obesity may also alter the clinical presentation in patients with primary hyperparathyroidism (PHPT).
objectivesThe objectives of the study were to compare the clinical presentation of obese (OB) vs nonobese (NO) PHPT patients and to assess the impact of obesity on the presentation of PHPT independent of serum calcium and PTH. PATIENTS: Consecutive PHPT patients who underwent parathyroidectomy between 2003 and 2012 by a single surgical group participated in the study.
settingThe study was conducted at an academic medical center.
designCross-sectional review of records of preoperative demographic, historical, laboratory, and densitometry findings and intraoperative pathological findings were compared in OB vs NO patients.
main outcome measuresThe prevalence of nephrolithiasis and osteoporosis was measured.
resultsTwo hundred forty-seven PHPT patients were included in this analysis. Fifty percent were OB and 79% were women. Mean body mass index was 25.3 ± 3.3 and 36.0 ± 5.2 kg/m(2) in the NO and OB groups, respectively. Age, gender, and race distribution was similar between the two groups. Serum calcium was similar between the groups (11.0 ± 0.7 mg/dL in NO vs 11.1 ± 0.9 mg/dL in OB, P = .13), whereas sPTH was higher in OB (151 ± 70 vs 136 ± 69 pg/mL, P = .03). The OB group exhibited higher prevalence of hypercalciuria (urine calcium > 400 mg per 24 h) (41% vs 23% in NO, P = .01) and nephrolithiasis (36% vs 21% in NO, P = .03). Despite higher sPTH, OB patients showed higher bone mineral density and a lower rate of osteoporosis (21% vs 35%, P = .05). Differences in the prevalence of hypercalciuria and osteoporosis between the groups persisted after adjustment for age, race, estimated glomerular filtration rate, gender, sPTH, and calcium.
conclusionsIn PHPT patients, obesity is a risk factor for hypercalciuria and nephrolithiasis and is protective against osteoporosis. The impact of parathyroidectomy on the clinical features of obese PHPT patients merits further evaluation.
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