ArticleBrain and behavior2014
Neural substrates of socioemotional self-awareness in neurodegenerative disease.
Article in Brain and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Awareness impairment in Alzheimer's disease and frontotemporal dementia: a systematic MRI review.Journal of neurology · 2023Pooled it
- Ethnicity, minority status, and inter-group bias: A systematic meta-analysis on fMRI studies.Frontiers in human neuroscience · 2022Pooled it
- Exploring the Relationship Between Deficits in Social Cognition and Neurodegenerative Dementia: A Systematic Review.Frontiers in aging neuroscience · 2022Pooled it
- Neural correlates of altered insight in frontotemporal dementia: a systematic review.NeuroImage. Clinical · 2019Pooled it
- Empathy in primary progressive aphasia: Neural signatures and longitudinal trajectories.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Unveiling discrepancies in depression detection among persons with dementia: A comparative analysis of caregiver and self-report.Journal of Alzheimer's disease : JAD · 2026Article
- Social Cognition in Community Dwelling Persons With Dementia; Is Facial Emotion Recognition Related to Proxy Rated Empathy and Aggression?International journal of geriatric psychiatry · 2026Article
- Reference-Group Adjusted Behavioural Dysfunction Questionnaire Score Discriminates Highly Behavioural-Variant Frontotemporal Dementia From Major Depressive Disorder and Alzheimer's Disease Dementia.European journal of neurology · 2025Article
- Clinical Manifestations and Neural Basis of Semantic Dementia: Converging Evidences From Brain Imaging Studies.Clinical interventions in aging · 2025Review
- Transdiagnostic Network Localization of Social, Language, and Motor Symptoms in Patients With Frontotemporal Lobar Degeneration.Neurology · 2024Article
- Discrepancies in Patient and Caregiver Ratings of Personality Change in Alzheimer's Disease and Related Dementias.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Awareness of Social Functioning in People with Dementia and Its Association with Dementia Severity: Multi-Center Cross-Sectional Study.Journal of Alzheimer's disease : JAD · 2024Article
- Social and non-social working memory in neurodegeneration.Neurobiology of disease · 2023Article
- Behavioral variant frontotemporal dementia in patients with primary psychiatric disorder: A magnetic resonance imaging study.Brain and behavior · 2023Article
- Amygdala but not hippocampal damage associated with smaller social network size.Neuropsychologia · 2022Article
- What Are the Neural Correlates of Impaired Awareness of Social Cognition and Function in Dementia? A Systematic Review.Brain sciences · 2022Review
- Anosognosia in Dementia: Evaluation of Perfusion Correlates Using 99mTc-HMPAO SPECT and Automated Brodmann Areas Analysis.Diagnostics (Basel, Switzerland) · 2022Article
- Social cognition in the FTLD spectrum: evidence from MRI.Journal of neurology · 2022Review
- Measuring social cognition in frontotemporal lobar degeneration: a clinical approach.Journal of neurology · 2022Review
- Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundNeuroimaging studies examining neural substrates of impaired self-awareness in patients with neurodegenerative diseases have shown divergent results depending on the modality (cognitive, emotional, behavioral) of awareness. Evidence is accumulating to suggest that self-awareness arises from a combination of modality-specific and large-scale supramodal neural networks.
methodsWe investigated the structural substrates of patients' tendency to overestimate or underestimate their own capacity to demonstrate empathic concern for others. Subjects' level of empathic concern was measured using the Interpersonal Reactivity Index, and subject-informant discrepancy scores were used to predict regional atrophy pattern, using voxel-based morphometry analysis. Of the 102 subjects, 83 were patients with neurodegenerative diseases such as behavioral variant frontotemporal dementia (bvFTD) or semantic variant primary progressive aphasia (svPPA); the other 19 were healthy older adults.
resultsbvFTD and svPPA patients typically overestimated their level of empathic concern compared to controls, and overestimating one's empathic concern predicted damage to predominantly right-hemispheric anterior infero-lateral temporal regions, whereas underestimating one's empathic concern showed no neuroanatomical basis.
conclusionsThese findings suggest that overestimation and underestimation of one's capacity for empathic concern cannot be interpreted as varying degrees of the same phenomenon, but may arise from different pathophysiological processes. Damage to anterior infero-lateral temporal regions has been associated with semantic self-knowledge, emotion processing, and social perspective taking; neuropsychological functions partly associated with empathic concern itself. These findings support the hypothesis that-at least in the socioemotional domain-neural substrates of self-awareness are partly modality-specific.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.