ArticleBrain and behavior2014
Unilateral disruptions in the default network with aging in native space.
Article in Brain and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis.Human brain mapping · 2020Trial
- A Fully Automatic Technique for Precise Localization and Quantification of Amyloid-β PET Scans.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Trial
- Changes in Neural Connectivity and Memory Following a Yoga Intervention for Older Adults: A Pilot Study.Journal of Alzheimer's disease : JAD · 2016Trial
- Brain signal variability during rest as a neural mechanism underlying cognitive reserve.NeuroImage · 2026Article
- Financial Decision Making in Older Adults Is Associated With Frontoparietal-Salience Between-Network Connectivity.Journal of neuroscience, psychology, and economics · 2026Article
- Integrating individualized connectome with amyloid pathology improves predictive modeling of future cognitive decline.Communications medicine · 2025Article
- Article
- Cross-sectional and Longitudinal Age-related Disintegration in Functional Connectivity: Reference Ability Neural Network Cohort.Journal of cognitive neuroscience · 2024Article
- Simple topological task-based functional connectivity features predict longitudinal behavioral change of fluid reasoning in the RANN cohort.NeuroImage · 2023Article
- Persistent homology-based functional connectivity and its association with cognitive ability: Life-span study.Human brain mapping · 2023Article
- Evidence suggesting common mechanisms underlie contralateral and ipsilateral negative BOLD responses in the human visual cortex.NeuroImage · 2022Article
- The role of neural flexibility in cognitive aging.NeuroImage · 2022Article
- Age-related disintegration in functional connectivity: Evidence from Reference Ability Neural Network (RANN) cohort.Neuropsychologia · 2021Article
- A framework for identification of a resting-bold connectome associated with cognitive reserve.NeuroImage · 2021Article
- Reference Ability Neural Network-selective functional connectivity across the lifespan.Human brain mapping · 2021Article
- Task-based functional connectivity in aging: How task and connectivity methodology affect discovery of age effects.Brain and behavior · 2021Article
- Article
- Associations between personality and whole-brain functional connectivity at rest: Evidence across the adult lifespan.Brain and behavior · 2020Article
- Brain Amyloid Burden and Resting-State Functional Connectivity in Late Middle-Aged Hispanics.Frontiers in neurology · 2020Article
- Task-evoked Negative BOLD Response and Functional Connectivity in the Default Mode Network are Representative of Two Overlapping but Separate Neurophysiological Processes.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundDisruption of the default-mode network (DMN) in healthy elders has been reported in many studies.
methodsIn a group of 51 participants (25 young, 26 elder) we examined DMN connectivity in subjects' native space. In the native space method, subject-specific regional masks (obtained independently for each subject) are used to extract regional fMRI times series. This approach substitutes the spatial normalization and subsequent smoothing used in prevailing methods, affords more accurate spatial localization, and provides the power to examine connectivity separately in the two hemispheres instead of averaging regions across hemispheres.
resultsThe native space method yielded new findings which were not detectable by the prevailing methods. The most reliable and robust disruption in elders' DMN connectivity were found between supramarginal gyrus and superior-frontal cortex in the right hemisphere only. The mean correlation between these two regions in young participants was about 0.5, and dropped significantly to 0.04 in elders (P = 2.1 × 10(-5)). In addition, the magnitude of functional connectivity between these regions in the right hemisphere correlated with memory (P = 0.05) and general fluid ability (P = 0.01) in elder participants and with speed of processing in young participants (P = 0.008). These relationships were not observed in the left hemisphere.
conclusionThese findings suggest that analysis of DMN connectivity in subjects' native space can improve localization and power and that it is important to examine connectivity separately in each hemisphere.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.