ArticlePostepy dermatologii i alergologii2014
Pro-inflammatory cytokines in patients with various kinds of acne treated with isotretinoin.
Article in Postepy dermatologii i alergologii, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Comparative radiologic characteristics of isotretinoin-induced sacroiliitis and axial spondyloarthritis.Irish journal of medical science · 2026Article
- Gentamicin and Citronella-Derived Compounds as Dual Modulators of Inflammation-Associated Targets in Acne Vulgaris.International journal of molecular sciences · 2025Article
- Acne Vulgaris Associated with Metabolic Syndrome: A Three-Case Series Highlighting Pathophysiological Links and Therapeutic Challenges.Diagnostics (Basel, Switzerland) · 2025Article
- Multifactorial Refractory Acne in Women: Insights from a Case Series Involving Hormonal-, Metabolic-, and Corticosteroid-Related Triggers.Life (Basel, Switzerland) · 2025Article
- Topical and Systemic Retinoids in the Management of Hidradenitis Suppurativa: A Comprehensive Literature Review.Dermatology and therapy · 2024Review
- Topical Administration ofMicroorganisms · 2023Article
- Evaluation of musculoskeletal adverse effects in patients on systemic isotretinoin treatment: A cross-sectional study.Archives of rheumatology · 2022Article
- Isotretinoin-induced sacroiliitis in patients with hidradenitis suppurativa: a case-based review.Rheumatology international · 2019Review
- The safety of isotretinoin treatment in patients with bone fractures.Postepy dermatologii i alergologii · 2019Review
- Significance of diet in treated and untreated acne vulgaris.Postepy dermatologii i alergologii · 2016Review
- Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population.Postepy dermatologii i alergologii · 2015Article
- Acne in hirsute women.Postepy dermatologii i alergologii · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcne vulgaris is the most frequently diagnosed dermatosis in patients aged between 11 and 30. It is believed that it affects about 80% of persons in this age group or even, taking into account lesions of low intensity, 100% of young people. The role of cytokines in the pathogenesis of acne is not fully known. The TLR2 receptors play a role in the aetiology of acne. Stimulation of TLR2 by Propionibacterium acnes makes the IL-8 and IL-12 concentrations increase.
aimThe aim of this work was to determine IL-1β, IL-1α, IL-8 and TNF-α levels in patients' sera used to test response to TLR2 stimulation. A decrease in the levels of the above mentioned cytokines together with a decrease in sebum production were defined as an indication of efficient treatment with isotretinoin. MATERIAL AND
methodsThe tests were performed in 155 patients treated for different clinical forms of acne with an oral isotretinoin preparation in the Dermatology Clinic of the Silesian Medical University in Katowice in 2009-2011 - I group and the patients treated with oral isotretinoin 2 and 5 years ago - II group. The control group consisted of 40 healthy individuals.
conclusionsMeasurements of IL-1α, IL-1β and TNF-α sera concentrations could be assessed in parallel to the improvement of the clinical condition and can constitute a good indication of the efficiency of the isotretinoin treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.